Hidden hearing loss selectively impairs neural adaptation to loud sound environments.
Hidden hearing loss selectively impairs neural adaptation to loud sound environments.
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DOI：
10.1038/s41467-018-06777-y
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发表时间：
2018-10-16
影响因子：
16.6
通讯作者：
Schaette R
中科院分区：
文献类型：
--
作者：
Bakay WMH;Anderson LA;Garcia-Lazaro JA;McAlpine D;Schaette R
即使接触一次大声噪音也会损害耳蜗毛细胞和听觉神经纤维之间的突触，导致听力测试无法检测到的隐性听力损失 (HHL)。在这里，我们通过测量小鼠听觉中脑神经元适应包含安静和大声时段的声音环境的能力，研究噪声诱导的 HHL 对功能性听力的影响。暴露于噪音的小鼠的神经元对嘈杂环境的适应能力较低，在这些环境中传递的有关声音强度的信息较少，并且对波动声音环境的长期统计结构的适应能力受到损害。自适应包括阈值自适应和增益自适应的级联。尽管噪声暴露仅直接损害阈值适应，但增益适应的保留功能令人惊讶地加剧了嘈杂环境的编码缺陷。这些缺陷可能有助于理解为什么许多看似听力正常的人在背景噪音中难以听清对话。隐性听力损失 (HHL) 是由于在听力图显示听力阈值变化之前内耳毛细胞突触的细微损伤而引起的。在这里，作者报告说，小鼠模型中的 HHL 破坏了中枢听觉系统中大声环境的神经编码。
Exposure to even a single episode of loud noise can damage synapses between cochlear hair cells and auditory nerve fibres, causing hidden hearing loss (HHL) that is not detected by audiometry. Here we investigate the effects of noise-induced HHL on functional hearing by measuring the ability of neurons in the auditory midbrain of mice to adapt to sound environments containing quiet and loud periods. Neurons from noise-exposed mice show less capacity for adaptation to loud environments, convey less information about sound intensity in those environments, and adaptation to the longer-term statistical structure of fluctuating sound environments is impaired. Adaptation comprises a cascade of both threshold and gain adaptation. Although noise exposure only impairs threshold adaptation directly, the preserved function of gain adaptation surprisingly aggravates coding deficits for loud environments. These deficits might help to understand why many individuals with seemingly normal hearing struggle to follow a conversation in background noise. Hidden hearing loss (HHL) arises through subtle damage to the synapses of hair cells in the inner ear before audiograms reveal hearing threshold shifts. Here, the authors report that HHL in a mouse model disrupts the neural encoding of loud sound environments in the central auditory system.
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影响因子：
3
作者：
Bharadwaj HM;Verhulst S;Shaheen L;Liberman MC;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG
影响因子：
4.3
作者：
Gilles A;Schlee W;Rabau S;Wouters K;Fransen E;Van de Heyning P
通讯作者：
Van de Heyning P
影响因子：
16.2
作者：
Chambers AR;Resnik J;Yuan Y;Whitton JP;Edge AS;Liberman MC;Polley DB
通讯作者：
Polley DB
影响因子：
3.4
作者：
Hesse, Lara Li;Bakay, Warren;Schaette, Roland
通讯作者：
Schaette, Roland
DOI：
10.1017/s0022215100050465
发表时间：
1955-02-01
期刊：
The Journal of laryngology and otology
影响因子：
--
作者：
SCHUKNECHT, H F;WOELLNER, R C
通讯作者：
WOELLNER, R C