Safety and efficacy of larval therapy on treating leg ulcers: a protocol for systematic review and meta-analysis.
Safety and efficacy of larval therapy on treating leg ulcers: a protocol for systematic review and meta-analysis.
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幼虫疗法治疗腿部溃疡的安全性和有效性：系统评价和荟萃分析方案
DOI：
10.1136/bmjopen-2020-039898
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发表时间：
2020-10-08
期刊：
影响因子：
2.9
通讯作者：
Liu G
中科院分区：
文献类型：
--
作者：
Fan W;Yang B;Hu X;Yang X;Shi C;Liu G
Introduction Leg ulcers (LUs) not only seriously affect life and work of patients, but also bring huge economic burden to the society. As a potential underused biological debridement, larval therapy provides help for the treatment of LUs. The purpose of our research is to assess whether patients with LUs can benefit from larval therapy. Methods and analysis The following electronic databases will be searched: PubMed, EMBASE, Web of Science, the Cochrane Library, China National Knowledge Infrastructure Database, Wanfang Database and Chinese Biological Medicine. Randomised controlled trials are eligible for inclusion. There will be no restrictions with respect to language and search date is up to June 2020. Primary outcomes investigated are complete healing rate after treatment, time to ulcer healing, reduction of wound surface area and adverse events. Risk ratios will be used for categorical data; weighted mean difference will be used for measurement data. Subgroup analysis and sensitivity analysis will be considered if heterogeneity exists. The results of data synthesis will be performed by narrative summary and quantitative analysis. Ethics and dissemination This systematic review does not require the approval of the ethics committee because individual data on patients are not collected. The results of the study will be disseminated in peer-reviewed journals. PROSPERO registration number CRD42020176953.
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DOI：
10.1111/dme.12509
发表时间：
2014-09
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Armstrong DG;Hanft JR;Driver VR;Smith AP;Lazaro-Martinez JL;Reyzelman AM;Furst GJ;Vayser DJ;Cervantes HL;Snyder RJ;Moore MF;May PE;Nelson JL;Baggs GE;Voss AC;Diabetic Foot Nutrition Study Group
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Diabetic Foot Nutrition Study Group
影响因子：
13.8
作者：
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Kirsner, Robert S.
DOI：
10.1097/won.0000000000000496
发表时间：
2019-01-01
影响因子：
2.6
作者：
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通讯作者：
Totonchi, Mehrangiz
DOI：
10.1136/bmj.b773
发表时间：
2009-03-19
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Dumville JC;Worthy G;Bland JM;Cullum N;Dowson C;Iglesias C;Mitchell JL;Nelson EA;Soares MO;Torgerson DJ;VenUS II team
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VenUS II team
影响因子：
5.6
作者：
Margolis, DJ;Bilker, W;Strom, BL
通讯作者：
Strom, BL