Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children.
Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children.
复制标题
长期蛋白质摄入量和膳食潜在肾酸负荷与健康儿童近端桡骨的骨建模和重塑相关。
DOI：
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发表时间：
2005
影响因子：
7.1
通讯作者：
E. Schoenau
中科院分区：
文献类型：
--
作者：
U. Alexy;T. Remer;F. Manz;C. Neu;E. Schoenau
背景
蛋白质和碱化矿物质越来越多地被描述为在影响骨状态方面发挥重要作用，不仅在老年人中，而且在儿童和青少年中。
目的
我们研究了长期膳食蛋白质摄入量和膳食净酸负荷是否与儿童的骨状况有关。
设计
在一项前瞻性研究设计中，229名6-18岁的健康儿童和青少年的长期饮食摄入量是根据3-d称重的饮食记录计算的，这些记录是在一次性骨分析之前每年收集的4年期间。膳食酸负荷的特点是潜在的肾脏酸负荷（PRAL）通过使用一个算法，包括膳食蛋白质，磷，镁，钾。通过外周定量计算机断层扫描测量前臂近端骨变量。
结果
在调整了年龄、性别和能量摄入，并控制了前臂肌肉发达程度、体重指数、生长速度和青春期发育后，我们观察到长期膳食蛋白质摄入与骨膜周长显著正相关（P < 0.01），反映了骨的造型，并与皮质面积骨矿含量（P <0.01）、极性强度应变指数（P < 0.0001），反映了造模与重塑的结合。高膳食PRAL的儿童皮质面积（P < 0.05）和骨矿物质含量（P < 0.01）显著降低。长期钙摄入对任何骨骼变量都没有显著影响。
结论
长期的膳食蛋白质摄入量似乎在生长过程中对骨干骨强度起合成代谢作用，如果膳食PRAL高，即如果碱性矿物质的摄入量低，这可能至少部分被否定。
BACKGROUND
Protein and alkalizing minerals are increasingly described as playing a major role in influencing bone status, not only in the elderly but also in children and adolescents.
OBJECTIVE
We examined whether the long-term dietary protein intake and diet net acid load are associated with bone status in children.
DESIGN
In a prospective study design in 229 healthy children and adolescents aged 6-18 y, long-term dietary intakes were calculated from 3-d weighed dietary records that were collected yearly over the 4-y period before a one-time bone analysis. Dietary acid load was characterized as potential renal acid load (PRAL) by using an algorithm including dietary protein, phosphorus, magnesium, and potassium. Proximal forearm bone variables were measured by peripheral quantitative computed tomography.
RESULTS
After adjustment for age, sex, and energy intake and control for forearm muscularity, BMI, growth velocity, and pubertal development, we observed that long-term dietary protein intake was significantly positively associated with periosteal circumference (P < 0.01), which reflected bone modeling, and with cortical area (P < 0.001), bone mineral content (P < 0.01), and polar strength strain index (P < 0.0001), which reflected a combination of modeling and remodeling. Children with a higher dietary PRAL had significantly less cortical area (P < 0.05) and bone mineral content (P < 0.01). Long-term calcium intake had no significant effect on any bone variable.
CONCLUSIONS
Long-term dietary protein intake appears to act anabolically on diaphyseal bone strength during growth, and this may be negated, at least partly, if dietary PRAL is high, ie, if the intake of alkalizing minerals is low.
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影响因子：
7.1
作者：
Kerstetter, JE;O'Brien, KO;Insogna, KL
通讯作者：
Insogna, KL
影响因子：
158.5
作者：
Appel, LJ;Moore, TJ;Karanja, N
通讯作者：
Karanja, N
低蛋白饮食引起的甲状旁腺激素升高的阈值。
DOI：
10.1093/ajcn/72.1.168
发表时间：
2000
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Kerstetter,JE;Svastisalee,CM;Caseria,DM;Mitnick,ME;Insogna,KL
通讯作者：
Insogna,KL
DOI：
10.1172/jci15463
发表时间：
2002-09
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
S. Yakar;C. Rosen;W. Beamer;C. Ackert-Bicknell;Yiping Wu;Jun-li Liu;G. Ooi;Jennifer Setser;J. Frystyk;Y. Boisclair;D. Leroith
通讯作者：
S. Yakar;C. Rosen;W. Beamer;C. Ackert-Bicknell;Yiping Wu;Jun-li Liu;G. Ooi;Jennifer Setser;J. Frystyk;Y. Boisclair;D. Leroith
影响因子：
7.1
作者：
Tucker, KL;Chen, HL;Kiel, DP
通讯作者：
Kiel, DP