Studies of tonotopy based on wave N100 of the auditory evoked field are problematic
Studies of tonotopy based on wave N100 of the auditory evoked field are problematic
复制标题
基于听觉诱发场波 N100 的音调研究存在问题
DOI：
10.1016/s1053-8119(03)00172-1
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发表时间：
2003
期刊：
影响因子：
5.7
通讯作者：
A. Seither
中科院分区：
文献类型：
--
作者：
B. Lütkenhöner;K. Krumbholz;A. Seither
听觉诱发场（AEF）是否反映了听觉皮层的音调特性，目前还存在争议。尽管如此，特别是在刺激开始后约100 ms（N100 m）出现的明显AEF波越来越多地用于研究诸如皮质重组和虚拟音高表示等问题。因此，似乎是时候对N100m发生器的假定音调组织进行关键的重新评估了。在目前的脑磁图研究中，对500 ms持续时间的短纯音的反应，单耳呈现高于阈值60 dB，用37通道轴向梯度计系统记录在半球对侧的刺激。刺激频率为250、500、1000和2000 Hz。每种类型的大约250个刺激以随机顺序在4个独立的会话中以均匀分布在2和2.8秒之间的间隔呈现。对10名听力正常受试者的19个半球进行的分析显示，个体内重复性很高，但个体间差异也很大。在大多数情况下，偶极子的位置要么没有表现出显着的频率依赖性，在所有，四个频率的偶极子没有有序对齐，或数据不符合单偶极子模型。在少数情况下，偶极子的安排与有序的tonotopic皮层地图的假设一致，最相关的坐标不同的主题。关于这些结果，似乎至关重要的是要了解波N100米的基础上，个别科目，而结论依赖于平均偶极子位置的受试者群体是有问题的。
There is still dissension as to whether the auditory evoked field (AEF) reflects tonotopy in the auditory cortex. That notwithstanding, particularly the pronounced AEF wave occurring about 100 ms after stimulus onset (N100m) is increasingly used for the investigation of issues such as cortical reorganization and representation of virtual pitch. Thus, it appears to be time for a critical revaluation of the supposed tonotopic organization of the N100m generator. In the present magnetoencephalography study, the response to tonebursts of 500 ms duration, monaurally presented 60 dB above threshold, was recorded with a 37-channel axial gradiometer system over the hemisphere contralateral to the side of stimulation. The stimulus frequencies were 250, 500, 1000, and 2000 Hz. About 250 stimuli of each type were presented in random order in four independent sessions at intervals uniformly distributed between 2 and 2.8 s. An analysis of 19 hemispheres in 10 normal-hearing subjects showed a high intraindividual reproducibility, but also a substantial interindividual variability. In most cases, the dipole location either exhibited no significant frequency dependence at all, the dipoles for the four frequencies were not orderly aligned, or the data disagreed with the single-dipole model. In the few cases showing an arrangement of dipoles consistent with the assumption of an orderly tonotopic cortical map, the most relevant coordinate varied from subject to subject. Regarding theses results, it seems crucial to understand wave N100m on the basis of individual subjects, whereas conclusions relying on mean dipole locations for groups of subjects are problematic.
影响因子：
2.5
作者：
Recanzone, GH;Guard, DC;Phan, ML
通讯作者：
Phan, ML
影响因子：
2.4
作者：
LIBERMAN, MC
通讯作者：
LIBERMAN, MC
影响因子：
3.7
作者：
Lockwood, AH;Salvi, RJ;Burkard, RF
通讯作者：
Burkard, RF