Mapping the evolution of regional brain network efficiency and its association with cognitive abilities during the first twenty-eight months of life.
Mapping the evolution of regional brain network efficiency and its association with cognitive abilities during the first twenty-eight months of life.
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DOI：
10.1016/j.dcn.2023.101284
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发表时间：
2023-10
影响因子：
4.7
通讯作者：
Lin, Weili
中科院分区：
文献类型：
--
作者：
Jiang, Weixiong;Zhou, Zhen;Li, Guoshi;Yin, Weiyan;Wu, Zhengwang;Wang, Li;Ghanbari, Maryam;Li, Gang;Yap, Pew-Thian;Howell, Brittany R.;Styner, Martin A.;Yacoub, Essa;Hazlett, Heather;Gilmore, John H.;Smith, J. Keith;Ugurbil, Kamil;Elison, Jed T.;Zhang, Han;Shen, Dinggang;Lin, Weili
人类的大脑在生命的最初几年经历了快速的发育。虽然以前的研究采用图论来研究早期大脑发育，但它主要集中在整个大脑的拓扑属性上。然而，研究区域图论特征可能会为认知能力的发展提供独特的见解。我们利用了来自NHTN/UMN婴儿连接组项目的大型纵向rsfMRI数据集，研究了区域效率的发展轨迹，并使用马伦早期学习量表评估了这些变化与生命前28个月认知能力之间的关系。我们的研究结果揭示了一个复杂的和时空异质性的区域，全球和本地的效率在这个年龄段的发展模式。此外，我们发现左颞枕梭状回和双侧枕梭状回的区域整体效率轨迹与认知能力呈正相关，包括视觉接收，表达语言，接受语言和早期学习综合评分（P < 0.05，FDR校正）。然而，这些联系随着年龄的增长而减弱。这些发现为大脑拓扑结构的区域发展特征及其与认知的关联提供了新的见解，并为全脑和区域水平上的大脑网络持续优化提供了证据。我们的论文以日常为基础绘制了大脑功能发展的图表。区域效率表现为与区域功能作用相关的时空异质性发展。梭状核区域整体效率的发展轨迹与认知能力呈正相关。
Human brain undergoes rapid growth during the first few years of life. While previous research has employed graph theory to study early brain development, it has mostly focused on the topological attributes of the whole brain. However, examining regional graph-theory features may provide unique insights into the development of cognitive abilities. Utilizing a large and longitudinal rsfMRI dataset from the UNC/UMN Baby Connectome Project, we investigated the developmental trajectories of regional efficiency and evaluated the relationships between these changes and cognitive abilities using Mullen Scales of Early Learning during the first twenty-eight months of life. Our results revealed a complex and spatiotemporally heterogeneous development pattern of regional global and local efficiency during this age period. Furthermore, we found that the trajectories of the regional global efficiency at the left temporal occipital fusiform and bilateral occipital fusiform gyri were positively associated with cognitive abilities, including visual reception, expressive language, receptive language, and early learning composite scores (P < 0.05, FDR corrected). However, these associations were weakened with age. These findings offered new insights into the regional developmental features of brain topologies and their associations with cognition and provided evidence of ongoing optimization of brain networks at both whole-brain and regional levels. Our paper charts brain functional development on a day-by-day basis. Regional efficiencies show spatiotemporal heterogeneous development related to regional functional roles. The developmental trajectories of regional global efficiency at the fusiform are positively associated with cognitive abilities.
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DOI：
10.1177/1073858416667720
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bassett DS;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
3.7
作者：
Tummeltshammer K;Amso D
通讯作者：
Amso D
影响因子：
4.6
作者：
De Asis-Cruz J;Bouyssi-Kobar M;Evangelou I;Vezina G;Limperopoulos C
通讯作者：
Limperopoulos C
影响因子：
3.7
作者：
D'Souza, Dean;D'Souza, Hana;Karmiloff-Smith, Annette
通讯作者：
Karmiloff-Smith, Annette
DOI：
10.1038/nrn.2018.1
发表时间：
2018-02-16
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gilmore JH;Knickmeyer RC;Gao W
通讯作者：
Gao W