Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases.
Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases.
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外泌体 MicroRNA 对神经退行性疾病的诊断和治疗潜力
DOI：
10.1155/2021/8884642
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发表时间：
2021
影响因子：
3.1
通讯作者：
Gao SG
中科院分区：
文献类型：
--
作者：
He M;Zhang HN;Tang ZC;Gao SG
神经退行性疾病（ND）的特征在于神经元和功能的逐渐丧失，最终导致进行性神经功能缺损。鉴于医疗保健系统的沉重负担，迫切需要用于早期诊断和治疗性治疗以逆转ND进展的有效且可靠的生物标志物。近年来，利用外泌体miRNA作为神经系统疾病的生物标志物或靶向治疗的研究越来越受到关注。本文综述了近年来有关外泌体miRNAs作为神经营养不良的生物标志物和潜在治疗方法的最新研究进展，以及它们与阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化（ALS）和亨廷顿病（HD）等神经营养不良的病理生理学关系。还鉴定并总结了在不同ND中通常失调或通常用作治疗候选物的外泌体miRNA。总之，外泌体miRNA作为ND的生物标志物和潜在靶向治疗的可行性已得到验证。然而，由于现有研究的局限性和不同研究之间的差异，仍然需要高质量的实验室和临床研究。
Neurodegenerative disorders (NDs) are characterized by a gradual loss of neurons and functions that eventually leads to progressive neurological impairment. In view of the heavy burden on the healthcare system, efficient and reliable biomarkers for early diagnosis and therapeutic treatments to reverse the progression of NDs are in urgent need. There has been an increasing interest in using exosomal miRNAs as biomarkers or targeted therapies for neurological diseases recently. In this review, we overviewed the updated studies on exosomal miRNAs as biomarkers and potential therapeutic approaches in NDs, as well as their association with the pathophysiology of this group of disorders, especially Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). The exosomal miRNAs that are commonly dysregulated across different NDs or are commonly used as therapeutic candidates were also identified and summarized. In summary, the feasibility of exosomal miRNAs as biomarkers and potential targeted therapy for NDs has been verified. However, due to the limitations of existing studies and the discrepancies across different studies, high quality laboratory and clinical investigations are still required.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
5.6
作者：
Finnerty JR;Wang WX;Hébert SS;Wilfred BR;Mao G;Nelson PT
通讯作者：
Nelson PT
DOI：
10.1016/j.apsb.2016.02.001
发表时间：
2016-07
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Ha D;Yang N;Nadithe V
通讯作者：
Nadithe V
影响因子：
4.3
作者：
Cha, Diana J.;Mengel, David;Walsh, Dominic M.
通讯作者：
Walsh, Dominic M.
影响因子：
8.6
作者：
Cooper, J. Mark;Wiklander, P. B. Oscar;Nordin, Joel Z.;Al-Shawi, Raya;Wood, Matthew J.;Vithlani, Mansi;Schapira, Anthony H. V.;Simons, J. Paul;El-Andaloussi, Samir;Alvarez-Erviti, Lydia
通讯作者：
Alvarez-Erviti, Lydia