TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment.
TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment.
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DOI：
10.3390/cancers13030401
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发表时间：
2021-01-22
期刊：
影响因子：
5.2
通讯作者：
Molon B
中科院分区：
文献类型：
--
作者：
Angioni R;Sánchez-Rodríguez R;Viola A;Molon B
代谢重编程是癌症的一个新兴标志。除了恶性区室，肿瘤微环境也经历代谢偏斜，有助于肿瘤进展和转移过程。越来越多的证据指出，转化生长因子β（TGF-β）作为癌症中多个细胞靶点的这些代谢变化的驱动因素，发挥着核心作用。本文综述了TGF-β介导的肿瘤微环境中基质细胞和免疫细胞群的代谢重编程的最新发现。特别是，我们仔细研究了当前的文献，以强调TGF-β级联中维持肿瘤中致耐受性程序的相关代谢检查点。克服肿瘤免疫抑制仍然是癌症免疫治疗的一项雄心勃勃的成就。值得注意的是，细胞因子TGF-β通过在宿主中建立耐受原性环境来促进多种癌症类型中的免疫逃避。事实上，它促进肿瘤微环境（TME）内免疫抑制调节细胞群的扩增和积累，在那里它还激活驻留的基质细胞并增强血管生成程序。最近，TGF-β也被证明是肿瘤中协调TME中代谢途径的关键代谢调节剂。在这篇综述中，我们将仔细研究TGF-β介导的免疫和基质细胞串扰TME内，主要集中在代谢程序。
Metabolic reprogramming is an emerging hallmark in cancer. Beside the malignant compartment, the tumor microenvironment also undergoes to a metabolic skewing, contributing to the neoplastic progression and metastasizing process. Growing evidence pointed out a central role for Transforming Growth Factor Beta (TGF-β) as a driver of these metabolic changes in multiple cellular targets in cancer. This review deals with very recent discoveries on TGF-β-mediated metabolic reprogramming of stromal and immune cell population within the tumor microenvironment. In particular, we scrutinized current literature to highlight relevant metabolic checkpoints in the TGF-β cascade that sustain tolerogenic programs in tumors. Overcoming tumor immunosuppression still represents one ambitious achievement for cancer immunotherapy. Of note, the cytokine TGF-β contributes to immune evasion in multiple cancer types, by feeding the establishment of a tolerogenic environment in the host. Indeed, it fosters the expansion and accumulation of immunosuppressive regulatory cell populations within the tumor microenvironment (TME), where it also activates resident stromal cells and enhances angiogenesis programs. More recently, TGF-β has also turned out as a key metabolic adjuster in tumors orchestrating metabolic pathways in the TME. In this review, we will scrutinize TGF-β-mediated immune and stromal cell crosstalk within the TME, with a primary focus on metabolic programs.
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影响因子：
--
作者：
Avagliano A;Granato G;Ruocco MR;Romano V;Belviso I;Carfora A;Montagnani S;Arcucci A
通讯作者：
Arcucci A
影响因子：
3.7
作者：
Byun, Hae-Ok;Jung, Hyun-Jung;Yoon, Gyesoon
通讯作者：
Yoon, Gyesoon
DOI：
10.1073/pnas.0408197102
发表时间：
2005-01-11
影响因子：
11.1
作者：
Chen, ML;Pittet, MJ;Khazaie, K
通讯作者：
Khazaie, K
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
影响因子：
50.3
作者：
Cantelmo AR;Conradi LC;Brajic A;Goveia J;Kalucka J;Pircher A;Chaturvedi P;Hol J;Thienpont B;Teuwen LA;Schoors S;Boeckx B;Vriens J;Kuchnio A;Veys K;Cruys B;Finotto L;Treps L;Stav-Noraas TE;Bifari F;Stapor P;Decimo I;Kampen K;De Bock K;Haraldsen G;Schoonjans L;Rabelink T;Eelen G;Ghesquière B;Rehman J;Lambrechts D;Malik AB;Dewerchin M;Carmeliet P
通讯作者：
Carmeliet P