Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts.
Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts.
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DOI：
10.1155/2018/6075403
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发表时间：
2018
影响因子：
--
通讯作者：
Arcucci A
中科院分区：
文献类型：
--
作者：
Avagliano A;Granato G;Ruocco MR;Romano V;Belviso I;Carfora A;Montagnani S;Arcucci A
癌症相关成纤维细胞（CAF）是实体肿瘤微环境的主要基质细胞类型，并且经历与生长因子、细胞因子的分泌和旁分泌相互作用相关的活化过程。实体瘤的重要特征之一是代谢重编程，其导致肿瘤细胞和CAF中的生物能量学和生物合成的变化。特别是，CAF遵循肿瘤疾病的演变并获得分解代谢表型：在肿瘤组织中，癌细胞和肿瘤微环境形成网络，其中癌细胞和CAF之间的串扰与细胞代谢重编程相关，这有助于CAF活化，癌症生长和进展以及逃避癌症治疗。在这方面，对CAF代谢重编程的研究可能有助于更好地了解其激活过程、基质和癌细胞之间的相互作用，并可以为开发能够根除CAF促肿瘤活性的新治疗策略提供创新工具。因此，本文重点介绍CAFs的代谢重编程与分化过程和癌症和基质细胞串扰。最后，针对CAFs代谢重编程的治疗反应和潜在的抗癌策略进行了综述。
Cancer associated fibroblasts (CAFs) are the main stromal cell type of solid tumour microenvironment and undergo an activation process associated with secretion of growth factors, cytokines, and paracrine interactions. One of the important features of solid tumours is the metabolic reprogramming that leads to changes of bioenergetics and biosynthesis in both tumour cells and CAFs. In particular, CAFs follow the evolution of tumour disease and acquire a catabolic phenotype: in tumour tissues, cancer cells and tumour microenvironment form a network where the crosstalk between cancer cells and CAFs is associated with cell metabolic reprogramming that contributes to CAFs activation, cancer growth, and progression and evasion from cancer therapies. In this regard, the study of CAFs metabolic reprogramming could contribute to better understand their activation process, the interaction between stroma, and cancer cells and could offer innovative tools for the development of new therapeutic strategies able to eradicate the protumorigenic activity of CAFs. Therefore, this review focuses on CAFs metabolic reprogramming associated with both differentiation process and cancer and stromal cells crosstalk. Finally, therapeutic responses and potential anticancer strategies targeting CAFs metabolic reprogramming are reviewed.
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