Viral phylodynamics.
Viral phylodynamics.
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DOI：
10.1371/journal.pcbi.1002947
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发表时间：
2013
影响因子：
4.3
通讯作者：
Bedford T
中科院分区：
文献类型：
--
作者：
Volz EM;Koelle K;Bedford T
病毒系统动力学被定义为研究流行病学、免疫学和进化过程如何作用并潜在地相互作用来塑造病毒的系统发育。自2004年创造这一术语以来，对病毒系统动力学的研究一直集中在传播动力学上，以努力阐明这些动力学如何影响病毒遗传变异。传播动态可以在受感染宿主内的细胞、种群内的单个宿主或整个宿主种群的水平上进行考虑。许多病毒，特别是RNA病毒，由于世代时间短和突变率高，会迅速积累遗传变异。因此，病毒遗传变异的模式很大程度上受传播速度的影响，也受传播实体相互传播的影响。病毒遗传变异的模式也会受到病毒表型选择的影响。尽管病毒在许多表型上可能不同，但迄今为止的系统动力学研究往往集中在有限数量的病毒表型上。这些表型包括毒力表型、与病毒传播性相关的表型、细胞或组织的嗜性表型以及有助于逃避宿主免疫的抗原表型。由于传播动力学和选择对病毒遗传变异的影响，病毒系统发育可用于研究重要的流行病学、免疫学和进化过程，如流行传播、时空动态(包括集合种群动态)、人畜共患病传播、组织嗜性和抗原漂移。通过考虑病毒系统发育来对这些过程进行定量研究是病毒系统动力学的中心目标。
Viral phylodynamics is defined as the study of how epidemiological, immunological, and evolutionary processes act and potentially interact to shape viral phylogenies. Since the coining of the term in 2004, research on viral phylodynamics has focused on transmission dynamics in an effort to shed light on how these dynamics impact viral genetic variation. Transmission dynamics can be considered at the level of cells within an infected host, individual hosts within a population, or entire populations of hosts. Many viruses, especially RNA viruses, rapidly accumulate genetic variation because of short generation times and high mutation rates. Patterns of viral genetic variation are therefore heavily influenced by how quickly transmission occurs and by which entities transmit to one another. Patterns of viral genetic variation will also be affected by selection acting on viral phenotypes. Although viruses can differ with respect to many phenotypes, phylodynamic studies have to date tended to focus on a limited number of viral phenotypes. These include virulence phenotypes, phenotypes associated with viral transmissibility, cell or tissue tropism phenotypes, and antigenic phenotypes that can facilitate escape from host immunity. Due to the impact that transmission dynamics and selection can have on viral genetic variation, viral phylogenies can therefore be used to investigate important epidemiological, immunological, and evolutionary processes, such as epidemic spread , spatio-temporal dynamics including metapopulation dynamics , zoonotic transmission, tissue tropism , and antigenic drift . The quantitative investigation of these processes through the consideration of viral phylogenies is the central aim of viral phylodynamics.
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影响因子：
10.7
作者：
Bhatt, Samir;Holmes, Edward C.;Pybus, Oliver G.
通讯作者：
Pybus, Oliver G.
DOI：
10.1073/pnas.0700741104
发表时间：
2007-05-08
影响因子：
11.1
作者：
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通讯作者：
Real, Leslie A.
DOI：
10.1073/pnas.0708559104
发表时间：
2007-10-30
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
10.7
作者：
Drummond, A;Forsberg, R;Rodrigo, AG
通讯作者：
Rodrigo, AG
影响因子：
64.8
作者：
Ferguson, NM;Galvani, AP;Bush, RM
通讯作者：
Bush, RM