Taxonomically restricted genes are associated with the evolution of sociality in the honey bee.
Taxonomically restricted genes are associated with the evolution of sociality in the honey bee.
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DOI：
10.1186/1471-2164-12-164
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发表时间：
2011-03-29
期刊：
影响因子：
4.4
通讯作者：
Tsutsui ND
中科院分区：
文献类型：
--
作者：
Johnson BR;Tsutsui ND
研究表明，分类学限制基因在数量上是显著的，并且对于谱系特异性性状的进化是重要的。社会性昆虫获得了许多新的形态和行为特征相对于他们的孤独的祖先。例如，高级社会性昆虫的任务库可以是40-50个任务，大约是独居黄蜂或蜜蜂的两倍。这种行为谱扩展的遗传基础仍然知之甚少，分类学限制基因的作用尚未在全基因组水平上探索。在这里，我们提出了比较基因组学的结果表明，分类学上限制的基因可能发挥了重要作用，在产生扩展的行为剧目与进化的真社会性。首先，我们表明，目前的蜜蜂官方基因集包含约700个分类限制基因。这些基因被分成孤儿基因、只在水翅目中发现的基因和只在昆虫中发现的基因。少数的孤儿或基因局限于Hyattera一直是实验工作的重点，但其中几个与新的真社会性特征或特征被认为已经从根本上改变了真社会性的结果。其次，我们预测，如果分类学上限制的基因是重要的，产生新的真社会性状，那么他们应该表达更高的频率在工人相对于女王，因为工人表现出大部分的新行为的蜜蜂相对于他们的孤独的祖先。我们找到了支持这一预测的证据。两倍的分类学限制的基因被发现之间的基因与较高的表达在工作相比，那些在皇后。最后，我们通过分析几个种姓特异性基因表达数据集，编制了一个广泛的参与真社会进化的候选分类学限制基因列表。这项工作确定了大量的候选分类学限制基因，可能发挥了作用，在真社会进化。因此，这项工作奠定了基础，为未来的功能基因组学工作的新奇性的进化背景下的社会行为。我们还提出了初步的证据，基于有偏见的基因表达模式，分类学上限制的基因可能发挥了作用，在种姓制度的演变，一个独特的血统特定的社会特征。
Studies have shown that taxonomically restricted genes are significant in number and important for the evolution of lineage specific traits. Social insects have gained many novel morphological and behavioral traits relative to their solitary ancestors. The task repertoire of an advanced social insect, for example, can be 40-50 tasks, about twice that of a solitary wasp or bee. The genetic basis of this expansion in behavioral repertoire is still poorly understood, and a role for taxonomically restricted genes has not been explored at the whole genome level. Here we present comparative genomics results suggesting that taxonomically restricted genes may have played an important role in generating the expansion of behavioral repertoire associated with the evolution of eusociality. First, we show that the current honey bee official gene set contains about 700 taxonomically restricted genes. These are split between orphans, genes found only in the Hymenoptera, and genes found only in insects. Few of the orphans or genes restricted to the Hymenoptera have been the focus of experimental work, but several of those that have are associated with novel eusocial traits or traits thought to have changed radically as a consequence of eusociality. Second, we predicted that if taxonomically restricted genes are important for generating novel eusocial traits, then they should be expressed with greater frequency in workers relative to the queen, as the workers exhibit most of the novel behavior of the honey bee relative to their solitary ancestors. We found support for this prediction. Twice as many taxonomically restricted genes were found amongst the genes with higher expression in workers compared to those with higher expression in queens. Finally, we compiled an extensive list of candidate taxonomically restricted genes involved in eusocial evolution by analyzing several caste specific gene expression data sets. This work identifies a large number of candidate taxonomically restricted genes that may have played a role in eusocial evolution. This work thus lays the foundation for future functional genomics work on the evolution of novelty in the context of social behavior. We also present preliminary evidence, based on biased patterns of gene expression, that taxonomically restricted genes may have played a role in the evolution of caste systems, a characteristic lineage specific social trait.
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影响因子：
2.3
作者：
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通讯作者：
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影响因子：
9.8
作者：
Khalturin, Konstantin;Anton-Erxleben, Friederike;Sassmann, Sylvia;Wittlieb, Joerg;Hemmrich, Georg;Bosch, Thomas C. G.
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Bosch, Thomas C. G.