Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies.
Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies.
复制标题
DOI：
10.1371/journal.pone.0009244
复制
发表时间：
2010-02-16
期刊：
影响因子：
3.7
通讯作者：
Deen JL
中科院分区：
文献类型：
--
作者：
Mtove G;Amos B;von Seidlein L;Hendriksen I;Mwambuli A;Kimera J;Mallahiyo R;Kim DR;Ochiai RL;Clemens JD;Reyburn H;Magesa S;Deen JL
The importance of invasive salmonellosis in African children is well recognized but there is inadequate information on these infections. We conducted a fever surveillance study in a Tanzanian rural hospital to estimate the case fraction of invasive salmonellosis among pediatric admissions, examine associations with common co-morbidities and describe its clinical features. We compared our main findings with those from previous studies among children in sub-Saharan Africa. From 1 March 2008 to 28 Feb 2009, 1,502 children were enrolled into the study. We collected clinical information and blood for point of care tests, culture, and diagnosis of malaria and HIV. We analyzed the clinical features on admission and outcome by laboratory-confirmed diagnosis. Pathogenic bacteria were isolated from the blood of 156 (10%) children, of which 14 (9%) were S. typhi, 45 (29%) were NTS and 97 (62%) were other pathogenic bacteria. Invasive salmonellosis accounted for 59/156 (38%) bacteremic children. Children with typhoid fever were significantly older and presented with a longer duration of fever. NTS infections were significantly associated with prior antimalarial treatment, malarial complications and with a high risk for death. Invasive salmonellosis, particularly NTS infection, is an important cause of febrile disease among hospitalized children in our rural Tanzanian setting. Previous studies showed considerable variation in the case fraction of S. typhi and NTS infections. Certain suggestive clinical features (such as older age and long duration of fever for typhoid whereas concomitant malaria, anemia, jaundice and hypoglycemia for NTS infection) may be used to distinguish invasive salmonellosis from other severe febrile illness.
登录
查看更多内容
乌干达坎帕拉的人类免疫缺陷病毒1感染和未感染的严重营养不良儿童中的菌血症。
影响因子：
3.7
作者：
Bachou, Hanifa;Tylleskar, Thorkild;Kaddu-Mulindwa, Deogratias H.;Tumwine, James K.
通讯作者：
Tumwine, James K.
DOI：
10.1016/s1201-9712(01)90067-0
发表时间：
2001-01-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Bahwere, P;Levy, J;De Mol, P
通讯作者：
De Mol, P
DOI：
10.1016/s0035-9203(99)90024-x
发表时间：
1999-05-01
影响因子：
2.2
作者：
Berkley, J;Mwarumba, S;Marsh, K
通讯作者：
Marsh, K
影响因子：
3.6
作者：
ODEMPSEY, TJD;MCARDLE, TF;GREENWOOD, BM
通讯作者：
GREENWOOD, BM
DOI：
10.1086/603553
发表时间：
2009-08-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Morpeth SC;Ramadhani HO;Crump JA
通讯作者：
Crump JA