Invasive non-Typhi Salmonella disease in Africa.
Invasive non-Typhi Salmonella disease in Africa.
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DOI：
10.1086/603553
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发表时间：
2009-08-15
期刊：
影响因子：
--
通讯作者：
Crump JA
中科院分区：
文献类型：
--
作者：
Morpeth SC;Ramadhani HO;Crump JA
Invasive non-Typhi Salmonella (NTS) is endemic in sub-Saharan Africa where it is a leading cause of bloodstream infection. Host risk factors have been established, but little is known about environmental reservoirs and predominant modes of transmission so prevention strategies are underdeveloped. While foodborne transmission from animals to humans predominates in high-income countries, it has been postulated that anthroponotic transmission both within and outside healthcare facilities may be important in sub-Saharan Africa. Antimicrobial resistance to ampicillin, trimethoprim-sulphamethoxazole and chloramphenicol is common; wider use of alternative agents may be warranted for empiric therapy. Vaccine development targeting the leading invasive NTS serotypes Typhimurium and Enteritidis shows promise. The clinical presentation of NTS bacteremia is non-specific and in the absence of blood culture may be confused with other febrile illnesses such as malaria. Much work remains to understand and control invasive NTS in sub-Saharan Africa.
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影响因子：
11.8
作者：
Crump, JA;Barrett, TJ;Angulo, FJ
通讯作者：
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影响因子：
11.8
作者：
Galanis, E;Wong, DMALF;WHO Global Salm Surv
通讯作者：
WHO Global Salm Surv
DOI：
10.1302/0301-620x.87b11.16735
发表时间：
2005-11-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Chang, Shan-Chwen
影响因子：
3
作者：
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通讯作者：
Hart, CA