Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
复制标题
DOI：
10.1002/mds.26987
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Movement Disorder Society-endorsed PSP Study Group
中科院分区：
文献类型：
--
作者：
Höglinger GU;Respondek G;Stamelou M;Kurz C;Josephs KA;Lang AE;Mollenhauer B;Müller U;Nilsson C;Whitwell JL;Arzberger T;Englund E;Gelpi E;Giese A;Irwin DJ;Meissner WG;Pantelyat A;Rajput A;van Swieten JC;Troakes C;Antonini A;Bhatia KP;Bordelon Y;Compta Y;Corvol JC;Colosimo C;Dickson DW;Dodel R;Ferguson L;Grossman M;Kassubek J;Krismer F;Levin J;Lorenzl S;Morris HR;Nestor P;Oertel WH;Poewe W;Rabinovici G;Rowe JB;Schellenberg GD;Seppi K;van Eimeren T;Wenning GK;Boxer AL;Golbe LI;Litvan I;Movement Disorder Society-endorsed PSP Study Group
PSP是神经病理学定义的疾病实体。1996年由国家神经疾病和中风研究所/PSP学会发表的临床诊断标准具有很好的特异性，但其敏感性仅限于Richardson综合征以外的各种PSP综合征。我们的目的是提供一个证据和共识为基础的修订PSP的临床诊断标准。我们检索PubMed、科克伦、Medline和PSYCInfo数据库中自1996年以来以英文发表的文章，使用死后诊断或高度特异性的临床标准作为诊断标准。其次，我们从尸检证实的PSP患者和对照疾病患者中产生了回顾性标准化临床数据。在此基础上，起草了诊断标准，在两次修改后的德尔菲评估中进行了优化，在为期2天的会议上提交了具有共识程序的结构化讨论，并在另外三轮德尔菲中进行了完善。定义的临床、影像学、实验室和遗传学结果作为强制性基本特征、强制性排除标准或背景依赖性排除标准。我们确定了四个功能领域（眼运动功能障碍，姿势不稳定，运动不能和认知功能障碍）作为PSP的临床预测因子。在这些领域中的每一个，我们提出了三个临床特征，有助于不同程度的诊断确定性。这些特征的特定组合定义了诊断标准，根据诊断确定性的三个程度（可能的PSP，可能的PSP和提示PSP）进行分层。临床线索和影像学表现为支持性特征。在这里，我们提出了新的标准，旨在优化PSP的早期，敏感和特异性的临床诊断的基础上，目前可用的证据。
PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson’s syndrome. We aimed to provide an evidence- and consensus-based revision of the clinical diagnostic criteria for PSP. We searched the PubMed, Cochrane, Medline, and PSYCInfo databases for articles published in English since 1996, using postmortem diagnosis or highly specific clinical criteria as the diagnostic standard. Second, we generated retrospective standardized clinical data from patients with autopsy-confirmed PSP and control diseases. On this basis, diagnostic criteria were drafted, optimized in two modified Delphi evaluations, submitted to structured discussions with consensus procedures during a 2-day meeting, and refined in three further Delphi rounds. Defined clinical, imaging, laboratory, and genetic findings serve as mandatory basic features, mandatory exclusion criteria, or context-dependent exclusion criteria. We identified four functional domains (ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction) as clinical predictors of PSP. Within each of these domains, we propose three clinical features that contribute different levels of diagnostic certainty. Specific combinations of these features define the diagnostic criteria, stratified by three degrees of diagnostic certainty (probable PSP, possible PSP, and suggestive of PSP). Clinical clues and imaging findings represent supportive features. Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence.
登录
查看更多内容
影响因子：
8.6
作者：
Birdi, S;Rajput, AH;George, D
通讯作者：
George, D
影响因子：
5
作者：
Ling, H.;de Silva, R.;Revesz, T.
通讯作者：
Revesz, T.
影响因子：
14.5
作者：
Ling, Helen;O'Sullivan, Sean S.;Lees, Andrew J.
通讯作者：
Lees, Andrew J.
影响因子：
2.4
作者：
Boeve, B;Dickson, D;Petersen, R
通讯作者：
Petersen, R
影响因子：
8.6
作者：
Compta, Yaroslau;Valideoriola, Francesc;Valls-Solé, Josep
通讯作者：
Valls-Solé, Josep