Generation of Monophasic Action Potentials and Intermediate Forms
Generation of Monophasic Action Potentials and Intermediate Forms
复制标题
单相动作电位和中间形式的生成
DOI：
10.1016/j.bpj.2020.05.039
复制
发表时间：
2020
影响因子：
3.4
通讯作者：
Fenton, Flavio H.
中科院分区：
文献类型：
--
作者：
Iravanian, Shahriar;Uzelac, Ilija;Herndon, Conner;Langberg, Jonathan J.;Fenton, Flavio H.
双相动作电位（MAP）是当电极被牢固地推靠心脏组织时记录的跨膜电位的近似复制品。尽管它有许多实际用途，MAP信号产生的机制以及它与单极记录如此不同的原因并不完全清楚，并且存在争议。在这项工作中，我们描述了一种方法来模拟现实的MAP和中间形式，这是多相电描记图从一个理想的MAP不同。我们的方法的关键思想是形成压缩区和交界处的空间区域的细胞外和浴或血池直接与电极接触，表现出压力引起的电导率降低和存在的一个复杂的网络的无源元件，作为一个高通滤波器，以扭曲和衰减的信号，到达记录放大器。该网络由被动组织特性和电极的双层电容之间的相互作用形成。MAP和中间形式存在于信号的连续体上，其可以通过模型参数的改变来生成。我们的模型有助于破译信号产生的机制，并可以导致电极，记录放大器和实验装置的更好的设计。
The monophasic action potential (MAP) is a near replica of the transmembrane potential recorded when an electrode is pushed firmly against cardiac tissue. Despite its many practical uses, the mechanism of MAP signal generation and the reason it is so different from unipolar recordings are not completely known and are a matter of controversy. In this work, we describe a method to simulate realistic MAP and intermediate forms, which are multiphasic electrograms different from an ideal MAP. The key ideas of our method are the formation of compressed zones and junctional spaces—regions of the extracellular and bath or blood pool directly in contact with electrodes that exhibit a pressure-induced reduction in electrical conductivity—and the presence of a complex network of passive components that acts as a high-pass filter to distort and attenuate the signal that reaches the recording amplifier. The network is formed by the interaction between the passive tissue properties and the double-layer capacitance of electrodes. The MAP and intermediate forms reside on a continuum of signals, which can be generated by the change of the model parameters. Our model helps to decipher the mechanisms of signal generation and can lead to a better design for electrodes, recording amplifiers, and experimental setups.
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影响因子：
4.6
作者：
Roth, BJ
通讯作者：
Roth, BJ
影响因子：
5.5
作者：
Fedorov, Vadim V.;Lozinsky, Ilya T.;Efimov, Igor R.
通讯作者：
Efimov, Igor R.
DOI：
--
发表时间：
1974
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
C. Ferris;L. R. Steward
通讯作者：
L. R. Steward
DOI：
10.1046/j.1540-8167.2002.01246.x
发表时间：
2002-12-01
影响因子：
2.7
作者：
Knollmann, BC;Tranquillo, J;Franz, MR
通讯作者：
Franz, MR
影响因子：
3.2
作者：
E. Vigmond;Dr. L. J. Leon
通讯作者：
Dr. L. J. Leon