Effects of hypoxia and hypercapnia on geniohyoid contractility and endurance.
Effects of hypoxia and hypercapnia on geniohyoid contractility and endurance.
复制标题
缺氧和高碳酸血症对颏舌骨收缩力和耐力的影响。
DOI：
10.1152/jappl.1991.71.2.709
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
VanLunteren,E
中科院分区：
文献类型：
--
作者：
Salmone,RJ;VanLunteren,E
睡眠呼吸暂停和其他呼吸系统疾病产生低氧血症和高碳酸血症，这些因素对骨骼肌的表现产生不利影响。为了研究这些化学变化对上呼吸道扩张肌产生力的影响，我们原位检测了严重缺氧（动脉PO2小于40托）、轻度缺氧（PO2 45-65托）和高碳酸血症（PCO2 55-80托）时膝舌骨肌的收缩和耐力特征，并与麻醉猫的高氧-正碳酸状态进行了比较。在最佳长度下研究肌肉，并通过对舌下神经（n = 7只猫）或膝舌骨肌（n = 2只猫）的最大上电刺激来评估收缩力。在低氧或高碳酸血症期间，颏舌骨肌的抽搐动力学或力-频率曲线无明显变化。然而，根据疲劳指数（在占空比为0.33的40 hz刺激下，2分钟时的力与初始力的比值），严重缺氧显著降低了膝舌骨的耐力，而高碳酸血症或轻度缺氧则没有。此外，重复刺激方案后的力-频率曲线在低氧时比高氧时向下移动更大，特别是在较高频率时。总之，膝舌骨肌在高水平激活时维持力量输出的能力会受到严重缺氧的不利影响，而轻度缺氧或高碳酸血症则不会。然而，这些化学扰动都不会严重影响肌肉收缩性。
Sleep apnea and other respiratory diseases produce hypoxemia and hypercapnia, factors that adversely affect skeletal muscle performance. To examine the effects of these chemical alterations on force production by an upper airway dilator muscle, the contractile and endurance characteristics of the geniohyoid muscle were examined in situ during severe hypoxia (arterial PO2 less than 40 Torr), mild hypoxia (PO2 45–65 Torr), and hypercapnia (PCO2 55–80 Torr) and compared with hyperoxic-normocapnic conditions in anesthetized cats. Muscles were studied at optimal length, and contractile force was assessed in response to supramaximal electrical stimulation of the hypoglossal nerve (n = 7 cats) or geniohyoid muscle (n = 2 cats). There were no significant changes in the twitch kinetics or force-frequency curve of the geniohyoid muscle during hypoxia or hypercapnia. However, the endurance of the geniohyoid, as reflected in the fatigue index (ratio of force at 2 min to initial force in response to 40-Hz stimulation at a duty cycle 0.33), was significantly reduced by severe hypoxia but not by hypercapnia or mild hypoxia. In addition, the downward shift in the force-frequency curve after the repetitive stimulation protocol was greater during hypoxia than hyperoxia, especially at higher frequencies. In conclusion, the ability of the geniohyoid muscle to maintain force output during high levels of activation is adversely affected by severe hypoxia but not mild hypoxia or hypercapnia. However, none of these chemical perturbations affected muscle contractility acutely.
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DOI：
--
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