Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.

Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
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DOI:
10.1038/bjc.1995.71
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发表时间:
1995-02
影响因子:
8.8
通讯作者:
Mancuso, S.
Mancuso, S.
中科院分区:
医学1区
文献类型:
--
作者:
Scambia, G.;Testa, U.;Benedetti Panici, P.;Foti, E.;Martucci, R.;Gadducci, A.;Perillo, A.;Facchini, V.;Peschle, C.;Mancuso, S.

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在114例原发性卵巢癌患者中,50%的患者IL-6水平升高。IL-6敏感性低于CA 125,两种测定的组合并不增加CA 125单独的敏感性。然而,升高的IL-6血清水平与不良预后相关,因为低IL-6水平的患者比高IL-6水平的患者具有更好的存活率(P = 0.0009)。多因素分析显示IL-6阳性有独立价值。
High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since patients with low IL-6 levels had a better survival than patients with high IL-6 levels (P = 0.0009). Multivariate analysis revealed that IL-6 positivity has an independent value.
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