Technical and clinical aspects of cortisol as a biochemical marker of chronic stress.
Technical and clinical aspects of cortisol as a biochemical marker of chronic stress.
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DOI：
10.5483/bmbrep.2015.48.4.275
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发表时间：
2015-04
期刊：
影响因子：
3.8
通讯作者：
Choi MH
中科院分区：
文献类型：
--
作者：
Lee DY;Kim E;Choi MH
压力现在被认为是一种普遍的病前因素，与各种慢性疾病的许多危险因素相关。急性压力可能会诱发个体对环境需求的适应性反应。然而，慢性过度压力会通过“失衡负荷”对健康结果产生累积的负面影响。因此，监测长期压力调节因子的量化水平将为预防或早期干预与压力相关的慢性疾病提供及时的机会。尽管可以通过测量心率、血压和各种代谢激素水平等生理参数的变化来量化急性或慢性压力，但仍难以解释皮质醇等压力介质循环水平的变化是否可以反映急性、慢性或昼夜变化。血清和唾液皮质醇水平都显示出单个时间点的急剧变化，但由于昼夜节律变化及其蛋白质结合能力，总体长期全身皮质醇暴露难以评估。头皮毛发的生长速度可预测，大约为每月 1 厘米，最 1 厘米的部分近似于上个月皮质醇产生量的平均值。头发中皮质醇的分析是一种用于回顾性评估慢性压力的非常有前途的技术。 [2015 年 BMB 报告； 48（4）：209-216]
Stress is now recognized as a universal premorbid factor associated with many risk factors of various chronic diseases. Acute stress may induce an individual’s adaptive response to environmental demands. However, chronic, excessive stress causes cumulative negative impacts on health outcomes through “allostatic load”. Thus, monitoring the quantified levels of long-term stress mediators would provide a timely opportunity for prevention or earlier intervention of stressrelated chronic illnesses. Although either acute or chronic stress could be quantified through measurement of changes in physiological parameters such as heart rate, blood pressure, and levels of various metabolic hormones, it is still elusive to interpret whether the changes in circulating levels of stress mediators such as cortisol can reflect the acute, chronic, or diurnal variations. Both serum and salivary cortisol levels reveal acute changes at a single point in time, but the overall long-term systemic cortisol exposure is difficult to evaluate due to circadian variations and its protein-binding capacity. Scalp hair has a fairy predictable growth rate of approximately 1 cm/month, and the most 1 cm segment approximates the last month’s cortisol production as the mean value. The analysis of cortisol in hair is a highly promising technique for the retrospective assessment of chronic stress. [BMB Reports 2015; 48(4): 209-216]
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