Autocrine and paracrine interferon signalling as 'ring vaccination' and 'contact tracing' strategies to suppress virus infection in a host.
Autocrine and paracrine interferon signalling as 'ring vaccination' and 'contact tracing' strategies to suppress virus infection in a host.
复制标题
DOI：
10.1098/rspb.2020.3002
复制
发表时间：
2021-02-24
期刊：
影响因子：
--
通讯作者：
Ke R
中科院分区：
文献类型：
--
作者：
Michael Lavigne G;Russell H;Sherry B;Ke R
先天免疫应答，特别是干扰素应答，代表了抵抗病毒感染的第一道防线。受感染细胞产生的干扰素分子通过自分泌和旁分泌信号作用，将宿主细胞转化为抗病毒状态。虽然IFN信号传导的分子机制已被很好地表征，但干扰素应答如何共同促进宿主细胞的调节以在早期感染期间停止或抑制病毒感染仍不清楚。在这里，我们使用数学模型来描绘的自分泌和旁分泌信号的作用，并表明它们对病毒传播的影响是依赖于感染的进展。特别是，我们发现，当感染混合良好时，旁分泌信号传导不那么有效;相反，当感染以空间方式传播时，组织中初始感染期间的可能情况，旁分泌信号传导可以通过减少靠近感染部位的易感细胞的数量来阻止感染的传播。此外，我们认为，干扰素反应可以被看作是一个平行的人口水平的流行病预防策略，如“接触者追踪”或“环接种”。因此，我们的研究结果可能对更广泛的人群规模的暴发控制具有影响。
The innate immune response, particularly the interferon response, represents a first line of defence against viral infections. The interferon molecules produced from infected cells act through autocrine and paracrine signalling to turn host cells into an antiviral state. Although the molecular mechanisms of IFN signalling have been well characterized, how the interferon response collectively contribute to the regulation of host cells to stop or suppress viral infection during early infection remain unclear. Here, we use mathematical models to delineate the roles of the autocrine and the paracrine signalling, and show that their impacts on viral spread are dependent on how infection proceeds. In particular, we found that when infection is well-mixed, the paracrine signalling is not as effective; by contrast, when infection spreads in a spatial manner, a likely scenario during initial infection in tissue, the paracrine signalling can impede the spread of infection by decreasing the number of susceptible cells close to the site of infection. Furthermore, we argue that the interferon response can be seen as a parallel to population-level epidemic prevention strategies such as ‘contact tracing’ or ‘ring vaccination’. Thus, our results here may have implications for the outbreak control at the population scale more broadly.
登录
查看更多内容
影响因子：
4.3
作者：
Graw, Frederik;Balagopal, Ashwin;Perelson, Alan S.
通讯作者：
Perelson, Alan S.
影响因子：
46.9
作者：
通讯作者：
--
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
DOI：
10.1038/s41577-019-0131-x
发表时间：
2019-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Altan-Bonnet G;Mukherjee R
通讯作者：
Mukherjee R
影响因子：
2
作者：
Beauchemin, C;Samuel, J;Tuszynski, J
通讯作者：
Tuszynski, J