Cytokine-mediated communication: a quantitative appraisal of immune complexity.
Cytokine-mediated communication: a quantitative appraisal of immune complexity.
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DOI：
10.1038/s41577-019-0131-x
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Mukherjee R
中科院分区：
文献类型：
--
作者：
Altan-Bonnet G;Mukherjee R
由细胞因子介导的细胞间通讯是免疫系统细胞相互“交谈”的主要机制。免疫系统中细胞因子信号传导的许多方面已经在结构、生物物理、生化和细胞水平上进行了详细的探索。然而，仍然缺乏对控制细胞因子介导的细胞间通讯的定量规则的系统理解。在这里，我们讨论系统免疫学领域最近的努力，以定量了解白细胞之间细胞因子介导的通讯，并为免疫反应和炎症的协调提供新的见解。系统免疫学的最新进展开始阐明控制细胞因子介导的细胞间通讯的定量规则。这篇综述描述了如何将理论分析与实验验证相结合，从而更好地理解细胞因子介导的免疫系统细胞之间的通讯。
Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system ‘talk’ to each other. Many aspects of cytokine signaling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Here, we discuss recent efforts in the field of systems immunology to bring about a quantitative understanding of cytokine-mediated communication between leukocytes and to provide novel insights into the orchestration of immune responses and inflammation. Recent advances in systems immunology are beginning to elucidate the quantitative rules that govern cytokine-mediated cell-to-cell communication. This Review describes how combining theoretical analysis with experimental validation can lead to a better understanding of cytokine-mediated communication between cells of the immune system.
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DOI：
10.1073/pnas.1615590114
发表时间：
2017-08-01
影响因子：
11.1
作者：
Eizenberg-Magar, Inbal;Rimer, Jacob;Friedman, Nir
通讯作者：
Friedman, Nir
感染期间淋巴结中中性粒细胞迁移的动态。
影响因子：
32.4
作者：
Chtanova, Tatyana;Schaeffer, Marie;Han, Seong-Ji;van Dooren, Giel G.;Nollmann, Marcelo;Herzmark, Paul;Chan, Shiao Wei;Satija, Harshita;Camfield, Kristin;Aaron, Holly;Striepen, Boris;Robey, Ellen A.
通讯作者：
Robey, Ellen A.
影响因子：
3.4
作者：
Coppey, Mathieu;Berezhkovskii, Alexander M.;Shvartsman, Stanislav Y.
通讯作者：
Shvartsman, Stanislav Y.
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
30.5
作者：
Davis MM;Tato CM;Furman D
通讯作者：
Furman D