Integrin and FAK Regulation of Human Pluripotent Stem Cells.
Integrin and FAK Regulation of Human Pluripotent Stem Cells.
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DOI：
10.1007/s40778-017-0100-x
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发表时间：
2017
影响因子：
1.4
通讯作者：
Kimber SJ
中科院分区：
文献类型：
--
作者：
Vitillo L;Kimber SJ
人多能干细胞（hPSC）是可在多种基质上培养并表达整联蛋白和整联蛋白信号传导机制的贴壁依赖性细胞。直到最近，人们对整合素信号传导如何调节多能干细胞（PSC）行为的理解仍然有限。本文综述了整合素和粘着斑激酶（FAK）如何调节hPSC生物学的不同方面。最新的研究表明，小鼠和人类胚胎干细胞利用类似的整合素信号传导参与者，但具有不同的生物学结果，反映了其多能状态的已知发育差异。值得注意的是，经由FAK信号传导的附着线索对于hPSC存活和多能性维持至关重要。FAK可以在皮质中发现，但也可以在与核心多能性网络相交的hPSC的细胞核中发现。整合素和FAK在PSC中的细胞粘附受体系统中具有传统的作用。这篇综述强调了数据表明，它们被牢固地整合在多能性电路中，对PSC培养的研究和临床应用的规模扩大和使用都有影响。
Human pluripotent stem cells (hPSCs) are anchorage-dependent cells that can be cultured on a variety of matrices and express integrins and the machinery for integrin signaling. Until recently, there has been limited understanding of exactly how integrin signaling regulates pluripotent stem cell (PSC) behavior. This review summarizes our knowledge of how integrins and focal adhesion kinase (FAK) regulate different aspects of hPSC biology. The latest research suggests that mouse and human embryonic stem cells utilize similar integrin signaling players but with different biological outcomes, reflecting the known developmental difference in their pluripotent status. Notably, attachment cues via FAK signaling are crucial for hPSCs survival and pluripotency maintenance. FAK may be found cortically but also in the nucleus of hPSCs intersecting core pluripotency networks. Integrins and FAK have been consigned to the conventional role of cell adhesion receptor systems in PSCs. This review highlights data indicating that they are firmly integrated in pluripotency circuits, with implications for both research PSC culture and scale up and use in clinical applications.
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