Activity in early visual areas predicts interindividual differences in binocular rivalry dynamics.
Activity in early visual areas predicts interindividual differences in binocular rivalry dynamics.
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DOI：
10.1152/jn.00509.2013
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发表时间：
2014-03
影响因子：
2.5
通讯作者：
Saiki J
中科院分区：
文献类型：
--
作者：
Yamashiro H;Yamamoto H;Mano H;Umeda M;Higuchi T;Saiki J
当两只眼睛呈现不同的图像时，就会发生双眼竞争（BR），并且感知会在图像之间自发地交替。尽管在视觉通路上的多个部位都发现了 BR 期间振荡知觉的神经相关性，但 BR 动态的来源尚不清楚。心理物理学和建模研究表明，低层和高层皮质过程都是 BR 动态的基础。先前的神经影像学研究通过显示额叶和顶叶皮质对 BR 中自发知觉交替的反应时间锁定，证明了高级区域的参与。然而，早期视觉区域对 BR 动态的潜在贡献被忽视了，因为这些区域也对模仿 BR 的物理刺激交替做出反应。在本研究中，我们没有关注知觉转换期间的活动，而是强调了抑制期间的大脑活动，以研究人类早期视觉区域的活动与 BR 动态之间的潜在联系。我们使用了一种称为连续闪光抑制的强眼间抑制范例来抑制和波动探针刺激的可见度，并使用功能性 MRI 测量对不可见探针开始时的视网膜专题反应。 12 名受试者的中位抑制持续时间存在约 130 倍的差异。抑制持续时间的个体差异可以通过不可见探针引起的纹外视觉区域（V3和V4v）中视网膜专题活动的幅度来预测。较弱的反应与较长的抑制持续时间相关。这些结果表明，早期视觉区域的视网膜专题表征在 BR 期间知觉交替的动态中发挥作用。
When dissimilar images are presented to the two eyes, binocular rivalry (BR) occurs, and perception alternates spontaneously between the images. Although neural correlates of the oscillating perception during BR have been found in multiple sites along the visual pathway, the source of BR dynamics is unclear. Psychophysical and modeling studies suggest that both low- and high-level cortical processes underlie BR dynamics. Previous neuroimaging studies have demonstrated the involvement of high-level regions by showing that frontal and parietal cortices responded time locked to spontaneous perceptual alternation in BR. However, a potential contribution of early visual areas to BR dynamics has been overlooked, because these areas also responded to the physical stimulus alternation mimicking BR. In the present study, instead of focusing on activity during perceptual switches, we highlighted brain activity during suppression periods to investigate a potential link between activity in human early visual areas and BR dynamics. We used a strong interocular suppression paradigm called continuous flash suppression to suppress and fluctuate the visibility of a probe stimulus and measured retinotopic responses to the onset of the invisible probe using functional MRI. There were ∼130-fold differences in the median suppression durations across 12 subjects. The individual differences in suppression durations could be predicted by the amplitudes of the retinotopic activity in extrastriate visual areas (V3 and V4v) evoked by the invisible probe. Weaker responses were associated with longer suppression durations. These results demonstrate that retinotopic representations in early visual areas play a role in the dynamics of perceptual alternations during BR.
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影响因子：
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