Quality of Life Is Independently Associated With Neurocognitive Function in Patients With Brain Tumors: Analysis of a Prospective Clinical Trial.
Quality of Life Is Independently Associated With Neurocognitive Function in Patients With Brain Tumors: Analysis of a Prospective Clinical Trial.
复制标题
DOI：
10.1016/j.ijrobp.2021.05.134
复制
发表时间：
2021-11-01
期刊：
影响因子：
--
通讯作者：
Hattangadi-Gluth JA
中科院分区：
文献类型：
--
作者：
Salans M;Tibbs MD;Huynh-Le MP;Yip A;Tringale K;Karunamuni R;Xu R;Reyes A;Macari AC;Pan-Weisz T;McDonald CR;Hattangadi-Gluth JA
We conducted the first prospective longitudinal study examining the independent association between patient-reported hrQoL (physical, social/family, emotional, functional, and brain cancer-specific) and neurocognitive function (NCF), while controlling for mood symptoms in primary brain tumor patients. Primary brain tumor patients (n=59) receiving brain radiotherapy (RT) underwent hrQOL (Functional Assessment of Cancer Therapy-Brain), mood (Beck Depression and Anxiety Inventories), and neurocognitive evaluation at baseline and 3, 6, and 12 months post-RT on a prospective clinical trial. Neurocognitive assessments measured attention/processing speed, memory, and executive function, including the Delis-Kaplan Executive Function System Verbal Fluency (DKEFS-VF), Hopkins Verbal Learning Test Revised (HVLT-R), and Brief Visuospatial Memory Test (BVMT). Subjects underwent neurocognitive, mood, and hrQoL assessments in the same testing session. Multivariable linear mixed-effects models assessed associations between hrQOL and NCF over time, controlling for patient, tumor, and treatment characteristics as well as timepoint-specific patient-reported mood (i.e., anxiety and depression symptoms). P-values were adjusted for multiple comparisons. Higher physical hrQoL was associated with better verbal memory (HVLT-R Total Recall p=0.047), while higher functional hrQoL was associated with better executive function (DKEFS-VF Switching Total p=0.009) and verbal memory (HVLT-R Delayed Recall p=0.006). Higher brain tumor-specific hrQoL was associated with better verbal and non-verbal memory (HVLT-R Total p=0.004 and Delayed Recall p=0.030; BVMT Total p=0.049 and Delayed Recall p=0.049). There was no association between social/family or emotional hrQoL and NCF after controlling for mood. Higher physical, functional, and brain tumor-specific hrQoL were associated with better executive function and memory among primary brain tumor patients. Physical and functional impairments are correlated with cognitive performance. Interventions to maximize quality of life after treatment may influence neurocognition, and vice versa.
登录
查看更多内容
影响因子：
6.2
作者：
Lin, Lin;Chiang, Hui-Hsun;Armstrong, Terri S.
通讯作者：
Armstrong, Terri S.
影响因子：
3.5
作者：
Ford, Kathleen;Sowers, MaryFran;Everson-Rose, Susan A.
通讯作者：
Everson-Rose, Susan A.
影响因子：
11
作者：
Giovagnoli, AR;Silvani, A;Boiardi, A
通讯作者：
Boiardi, A
影响因子：
11
作者：
GRAFMAN, J;SCHWARTZ, V;STRAUS, SE
通讯作者：
STRAUS, SE
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y