Ferroptosis in Glioma Immune Microenvironment: Opportunity and Challenge.
Ferroptosis in Glioma Immune Microenvironment: Opportunity and Challenge.
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DOI：
10.3389/fonc.2022.917634
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zhang, Jianmin
中科院分区：
文献类型：
--
作者：
Wang, Kaikai;Wang, Junjie;Zhang, Jiahao;Zhang, Anke;Liu, Yibo;Zhou, Jingyi;Wang, Xiaoyu;Zhang, Jianmin
脑胶质瘤是成人最常见的颅内恶性肿瘤，即使在确诊后接受Stupp治疗的患者中，其5年生存率也极低，这迫使我们探索更有效的临床策略。此时，免疫治疗在多种肿瘤的临床治疗中显示出巨大的潜力，但由于胶质瘤免疫抑制微环境诱导的肿瘤免疫赦免，其对胶质瘤的临床疗效有限，因此重塑免疫抑制微环境是消除胶质瘤免疫治疗耐药性的一条切实可行的途径。近年来，越来越多的研究证实，铁凋亡作为一种新的细胞死亡形式，在肿瘤的发生发展和免疫微环境中发挥着重要作用，其中铁凋亡与肿瘤免疫微环境之间的相互作用备受关注。本文就近年来胶质瘤免疫微环境中铁凋亡的研究进展作一综述。
Glioma is the most common intracranial malignant tumor in adults and the 5-year survival rate of glioma patients is extremely poor, even in patients who received Stupp treatment after diagnosis and this forces us to explore more efficient clinical strategies. At this time, immunotherapy shows great potential in a variety of tumor clinical treatments, however, its clinical effect in glioma is limited because of tumor immune privilege which was induced by the glioma immunosuppressive microenvironment, so remodeling the immunosuppressive microenvironment is a practical way to eliminate glioma immunotherapy resistance. Recently, increasing studies have confirmed that ferroptosis, a new form of cell death, plays an important role in tumor progression and immune microenvironment and the crosstalk between ferroptosis and tumor immune microenvironment attracts much attention. This work summarizes the progress studies of ferroptosis in the glioma immune microenvironment.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
13.3
作者：
Feng X;Zhang H;Meng L;Song H;Zhou Q;Qu C;Zhao P;Li Q;Zou C;Liu X;Zhang Z
通讯作者：
Zhang Z
影响因子：
16.6
作者：
Abdelfattah N;Kumar P;Wang C;Leu JS;Flynn WF;Gao R;Baskin DS;Pichumani K;Ijare OB;Wood SL;Powell SZ;Haviland DL;Parker Kerrigan BC;Lang FF;Prabhu SS;Huntoon KM;Jiang W;Kim BYS;George J;Yun K
通讯作者：
Yun K
影响因子：
15.9
作者：
Anh Nhat Tran;Walker, Kiera;Hjelmeland, Anita B.
通讯作者：
Hjelmeland, Anita B.
lncRNA TMEM161B-AS1的过表达通过海绵hsa-miR-27a-3p上调多个铁死亡相关基因的表达促进胶质瘤细胞的恶性生物学行为和对替莫唑胺的耐药性
影响因子：
7
作者：
Chen Q;Wang W;Wu Z;Chen S;Chen X;Zhuang S;Song G;Lv Y;Lin Y
通讯作者：
Lin Y