The Association Between Genetic Variation in FOXP2 and Sensorimotor Control of Speech Production.
The Association Between Genetic Variation in FOXP2 and Sensorimotor Control of Speech Production.
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FOXP2 遗传变异与言语产生的感觉运动控制之间的关联
DOI：
10.3389/fnins.2018.00666
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发表时间：
2018
影响因子：
4.3
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Zhang S;Zhao J;Guo Z;Jones JA;Liu P;Liu H
在理解听觉反馈在语音产生的感觉运动整合中的作用方面已经取得了重大进展。然而，这种基于反馈的控制过程的神经遗传学基础仍然很大程度上未知。人类 FOXP2 基因突变与言语运动行为的严重缺陷有关。本研究以 133 名中国成年人为样本，研究了 FOXP2 常见变异 rs6980093 (A/G) 与发声过程中 -50 和 -200 音调扰动的行为和事件相关电位 (ERP) 反应之间的关联。在行为上，相对于 AA 和 AG 基因型，GG 基因型与 -200 美分扰动的声音补偿显着较小相关。此外，AA和AG基因型在-50和-200音分扰动的声音补偿程度与正常语音基频的变异性之间表现出显着的正相关性，而GG基因型则不存在这种相关性。在皮质水平，与 AA 和 AG 基因型相比，GG 基因型对 -200 分扰动的 P2 反应显着更大，因为上、中、下额回、中央前回、前扣带皮层、颞中回和岛叶的左偏活动增加。然而，对 -50 美分扰动的神经行为反应并不随基因型的变化而变化。这些发现为 FOXP2 基因变异与音高调节的听觉运动整合之间的关联提供了第一个神经行为证据。 rs6980093 处 FOXP2 基因型的差异效应可能反映了它们对语音产生的反馈权重和前馈控制的影响。
Significant advances have been made in understanding the role of auditory feedback in sensorimotor integration for speech production. The neurogenetic basis of this feedback-based control process, however, remains largely unknown. Mutations of FOXP2 gene in humans are associated with severe deficits in speech motor behavior. The present study examined the associations between a FOXP2 common variant, rs6980093 (A/G), and the behavioral and event-related potential (ERP) responses to -50 and -200 cents pitch perturbations during vocal production in a sample of 133 Chinese adults. Behaviorally, the GG genotype was associated with significantly smaller vocal compensations for -200 cents perturbations relative to the AA and AG genotypes. Furthermore, both the AA and AG genotypes exhibited significant positive correlations between the degree of vocal compensation for -50 and -200 cents perturbations and the variability of normal voice fundamental frequency, whereas no such correlation existed for the GG genotype. At the cortical level, significantly larger P2 responses to -200 cents perturbations were associated with the GG genotype as compared to the AA and AG genotypes due to increased left-lateralized activity in the superior, middle, and inferior frontal gyrus, precentral gyrus, anterior cingulate cortex, middle temporal gyrus, and insula. The neurobehavioral responses to -50 cents perturbations, however, did not vary as a function of genotype. These findings present the first neurobehavioral evidence for an association between FOXP2 genetic variant and auditory-motor integration for vocal pitch regulation. The differential effects of FOXP2 genotypes at rs6980093 may reflect their influences on the weighting of feedback and feedforward control of speech production.
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影响因子：
5.3
作者：
Chandrasekaran, Bharath;Yi, Han-Gyol;Maddox, W. Todd
通讯作者：
Maddox, W. Todd
影响因子：
5.7
作者：
Behroozmand R;Shebek R;Hansen DR;Oya H;Robin DA;Howard MA 3rd;Greenlee JD
通讯作者：
Greenlee JD
影响因子：
9.2
作者：
Groszer, Matthias;Keays, David A.;Deacon, Robert M. J.;de Bono, Joseph P.;Prasad-Mulcare, Shweta;Gaub, Simone;Baum, Muriel G.;French, Catherine A.;Nicod, Jrme;Coventry, Julie A.;Enard, Wolfgang;Fray, Martin;Brown, Steve D. M.;Nolan, Patrick M.;Paeaebo, Svante;Channon, Keith M.;Costa, Rui M.;Eilers, Jens;Ehret, Guenter;Nicholas, J.;Rawlins, P.;Fisher, Simon E.
通讯作者：
Fisher, Simon E.
影响因子：
2.4
作者：
Burnett, TA;Freedland, MB;Hain, TC
通讯作者：
Hain, TC
影响因子：
5.7
作者：
Golfinopoulos, E.;Tourville, J. A.;Guenther, F. H.
通讯作者：
Guenther, F. H.