Differential Effects of 5-HTTLPR Genotypes on Inhibition of Negative Emotional Information Following Acute Stress Exposure and Tryptophan Challenge
Differential Effects of 5-HTTLPR Genotypes on Inhibition of Negative Emotional Information Following Acute Stress Exposure and Tryptophan Challenge
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5-HTTLPR 基因型对急性应激暴露和色氨酸挑战后负面情绪信息抑制的差异作用
DOI：
10.1038/npp.2010.221
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发表时间：
2011
影响因子：
7.6
通讯作者：
R. Raedt
中科院分区：
文献类型：
--
作者：
C. Markus;R. Raedt
以前的数据表明，在5-羟色胺（5-HT）转运体基因（5-HTTLPR）的多态性可能会影响压力恢复力和压力相关的抑郁症状，由于大脑5-HT功能障碍和压力暴露之间的相互作用。虽然在抑郁症中已经可靠地观察到对情绪信息的注意偏向，但尚未研究5-HT转运体连接启动子区（5-HTTLPR）、脑5-HT易损性和急性应激对情感信息加工的相互作用。本研究主要在女性S′/S′-和L′/L′-等位基因携带者中考察了色氨酸（TRP）增强（表明5-HT操纵）对应激条件下负面情绪信息抑制的影响。采用双盲、安慰剂对照设计，对15名女性纯合子短等位基因5-HTTLPR（S′/S′=S/S，S/LG，LG/LG）和13名女性纯合子长等位基因5-HTTLPR（L′/L′=LA/LA）受试者在TRP操作后应激暴露前后的情绪和情绪信息抑制进行了测试。应激暴露仅对S′/S′携带者的负性情感信息抑制能力产生显著损害，而L′/L′携带者的负性情感信息抑制能力甚至增强。S′/S′等位基因5-HTTLPR基因型增加了急性应激下对负性情绪信息的认知-注意偏向。由于这种偏见是抑郁症的一个重要组成部分，这可能是一个介导机制，使S′/S′-等位基因携带者更容易受到压力诱导的抑郁症状。此外，目前的数据表明，L′/L′-等位基因基因型更有弹性，甚至增加了压力后的认知情绪（抑制）控制。
Previous data suggest that a polymorphism at the serotonin (5-HT) transporter gene (5-HTTLPR) may influence stress resilience and stress-related depression symptoms due to interactions between brain 5-HT dysfunction and stress exposure. Although attentional bias for emotional information has been reliably observed in depression, the interaction between 5-HT transporter-linked promoter region (5-HTTLPR), brain 5-HT vulnerability, and acute stress on affective information processing has not yet been investigated. This study examines the effects of tryptophan (TRP) augmentation (indicating 5-HT manipulation) on inhibition of negative emotional information under stress in mainly female S′/S′- vs L′/L′-allele carriers. A total of 15 female homozygotic short-allele 5-HTTLPR (S′/S′=S/S, S/LG, LG/LG) and 13 female homozygotic long-allele 5-HTTLPR (L′/L′=LA/LA) subjects were tested for mood and inhibition of emotional information in a double-blind, placebo-controlled design before and after stress exposure following TRP manipulation. Stress exposure significantly impaired inhibition of negative affective information only in S′/S′ carriers, whereas L′/L′ carriers even showed increased inhibition of negative information. The S′/S′ allele 5-HTTLPR genotype increases cognitive-attentional bias for negative emotional information under acute stress. As this bias is an important component of depression, this may be a mediating mechanism making S′/S′-allele carriers more vulnerability for stress-induced depression symptoms. Moreover, current data suggest that L′/L′-allele genotypes are more resilient, even increasing cognitive emotional (inhibitory) control after stress.
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影响因子：
120.7
作者：
Risch, Neil;Herrell, Richard;Lehner, Thomas;Liang, Kung-Yee;Eaves, Lindon;Hoh, Josephine;Griem, Andrea;Kovacs, Maria;Ott, Jurg;Merikangas, Kathleen Ries
通讯作者：
Merikangas, Kathleen Ries
DOI：
10.1176/ajp.2006.163.9.1588
发表时间：
2006-09
期刊：
The American journal of psychiatry
影响因子：
--
作者：
G. Zalsman;Yung-yu Huang;M. Oquendo;A. Burke;Xian-zhang Hu;D. Brent;S. Ellis;D. Goldman;J. Mann-J
通讯作者：
G. Zalsman;Yung-yu Huang;M. Oquendo;A. Burke;Xian-zhang Hu;D. Brent;S. Ellis;D. Goldman;J. Mann-J
单胺和抗抑郁作用机制：儿茶酚胺消耗对接受抗抑郁药治疗的患者情绪的影响。
影响因子：
--
作者：
Delgado,PL;Miller,HL;Salomon,RM;Licinio,J;Heninger,GR;Gelenberg,AJ;Charney,DS
通讯作者：
Charney,DS
影响因子：
--
作者：
Delgado,PL;Charney,DS;Price,LH;Aghajanian,GK;Landis,H;Heninger,GR
通讯作者：
Heninger,GR
DOI：
10.1073/pnas.94.10.5308
发表时间：
1997-05-13
影响因子：
11.1
作者：
Nishizawa, S;Benkelfat, C;Diksic, M
通讯作者：
Diksic, M