Epoxylipids and soluble epoxide hydrolase in heart diseases.
Epoxylipids and soluble epoxide hydrolase in heart diseases.
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DOI：
10.1016/j.bcp.2021.114866
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发表时间：
2022-01
影响因子：
5.8
通讯作者：
Neckar J
中科院分区：
文献类型：
--
作者：
Imig JD;Cervenka L;Neckar J
心血管和心脏病是发病和死亡的主要原因。冠状动脉内皮和血管功能障碍、炎症和线粒体功能障碍有助于心脏病如心律失常、充血性心力衰竭和心脏病发作的进展。脂肪酸环氧脂的种类及其通过可溶性环氧化物水解酶（sEH）的酶促调节已经涉及心脏疾病中的冠状动脉功能障碍、炎症和线粒体功能障碍。同样，环氧脂的遗传和药理学操作已被证明对心脏病具有治疗益处。增加环氧脂减少心脏肥大和纤维化，改善心脏功能。环氧脂的有益作用已在心脏缺血再灌注损伤、电导异常和心律失常和室性心动过速中得到证实。这篇综述讨论了过去和最近的研究结果的贡献环氧脂在心脏病和潜在的操纵，以治疗心脏病发作，心律失常，室性心动过速，心力衰竭。
Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks. Classes of fatty acid epoxylipids and their enzymatic regulation by soluble epoxide hydrolase (sEH) have been implicated in coronary artery dysfunction, inflammation, and mitochondrial dysfunction in heart diseases. Likewise, genetic and pharmacological manipulations of epoxylipids have been demonstrated to have therapeutic benefits for heart diseases. Increasing epoxylipids reduce cardiac hypertrophy and fibrosis and improve cardiac function. Beneficial actions for epoxylipids have been demonstrated in cardiac ischemia reperfusion injury, electrical conductance abnormalities and arrhythmias, and ventricular tachycardia. This review discusses past and recent findings on the contribution of epoxylipids in heart diseases and the potential for their manipulation to treat heart attacks, arrhythmias, ventricular tachycardia, and heart failure.
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14,15-氯氧基-5,8,11-三烯酸（14,15-EET）替代物：羧酸盐修饰。
影响因子：
7.3
作者：
Falck JR;Koduru SR;Mohapatra S;Manne R;Atcha KR;Atcha R;Manthati VL;Capdevila JH;Christian S;Imig JD;Campbell WB
通讯作者：
Campbell WB
影响因子：
2.1
作者：
Červenka L;Melenovský V;Husková Z;Sporková A;Bürgelová M;Škaroupková P;Hwang SH;Hammock BD;Imig JD;Sadowski J
通讯作者：
Sadowski J
影响因子：
7.3
作者：
Batchu, S. N.;Lee, S. B.;Seubert, J. M.
通讯作者：
Seubert, J. M.
影响因子：
3
作者：
Chaudhary KR;Abukhashim M;Hwang SH;Hammock BD;Seubert JM
通讯作者：
Seubert JM
影响因子：
5
作者：
Batchu, Sri N.;Chaudhary, Ketul R.;Seubert, John M.
通讯作者：
Seubert, John M.