A computational model of inferior colliculus responses to amplitude modulated sounds in young and aged rats.
A computational model of inferior colliculus responses to amplitude modulated sounds in young and aged rats.
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DOI：
10.3389/fncir.2012.00077
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发表时间：
2012
影响因子：
3.5
通讯作者：
Bartlett EL
中科院分区：
文献类型：
--
作者：
Rabang CF;Parthasarathy A;Venkataraman Y;Fisher ZL;Gardner SM;Bartlett EL
下丘（IC）接收来自多个来源的上行兴奋性和抑制性输入，但这些听觉输入如何汇聚产生IC尖峰模式尚不清楚。模拟来自细胞和突触模型的体内尖峰序列数据模式，创建了一个强大的框架，以确定导致IC反应变化的因素，例如导致年龄相关的时间处理丧失的因素。构建基于电导的单神经元IC模型，并将其与大鼠体内IC记录的反应进行比较。使用高于阈值20-40 dB的调幅音调或噪声载波诱发IC尖峰图，并根据其速率调制传递函数调谐形状分类为低通、带通、带阻、全通或复杂。测量了它们的时间调制传递函数。这些脉冲模式提供了速率、矢量强度和发射模式的实验测量，以便与模型输出进行比较。兴奋性和抑制性突触收敛到IC神经元的模式基于解剖学研究和调制频率的广义输入调谐。模型上升输入的响应来源于以往研究的实验数据。通过钙激活的钾电流，建立了适应性和持续的IC内在模型。短期突触可塑性以突触抑制的形式被纳入模型，这被证明对IC反应的强度和时间过程有实质性影响。重建了最常见的IC反应亚型，并使遗传反应特性与IC中产生的反应特性分离开来。此外，该模型用于预测由于解剖学上看到的GABA随着年龄的增长而减少的与年龄相关的时间处理丧失的抑制减少的后果。
The inferior colliculus (IC) receives ascending excitatory and inhibitory inputs from multiple sources, but how these auditory inputs converge to generate IC spike patterns is poorly understood. Simulating patterns of in vivo spike train data from cellular and synaptic models creates a powerful framework to identify factors that contribute to changes in IC responses, such as those resulting in age-related loss of temporal processing. A conductance-based single neuron IC model was constructed, and its responses were compared to those observed during in vivo IC recordings in rats. IC spike patterns were evoked using amplitude-modulated tone or noise carriers at 20–40 dB above threshold and were classified as low-pass, band-pass, band-reject, all-pass, or complex based on their rate modulation transfer function tuning shape. Their temporal modulation transfer functions were also measured. These spike patterns provided experimental measures of rate, vector strength, and firing pattern for comparison with model outputs. Patterns of excitatory and inhibitory synaptic convergence to IC neurons were based on anatomical studies and generalized input tuning for modulation frequency. Responses of modeled ascending inputs were derived from experimental data from previous studies. Adapting and sustained IC intrinsic models were created, with adaptation created via calcium-activated potassium currents. Short-term synaptic plasticity was incorporated into the model in the form of synaptic depression, which was shown to have a substantial effect on the magnitude and time course of the IC response. The most commonly observed IC response sub-types were recreated and enabled dissociation of inherited response properties from those that were generated in IC. Furthermore, the model was used to make predictions about the consequences of reduction in inhibition for age-related loss of temporal processing due to a reduction in GABA seen anatomically with age.
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影响因子：
5.3
作者：
Elhilali, M;Fritz, JB;Shamma, SA
通讯作者：
Shamma, SA
影响因子：
1.2
作者：
Aradi, I;Holmes, WR
通讯作者：
Holmes, WR
影响因子：
2.5
作者：
Bal, R;Green, GGR;Sanders, DJ
通讯作者：
Sanders, DJ
影响因子：
2.5
作者：
GROTHE, B
通讯作者：
GROTHE, B
影响因子：
2.5
作者：
Geis, H. -R.;Borst, J. G. G.
通讯作者：
Borst, J. G. G.