The fraction of sensitization among lung transplant recipients in a transplant center in Japan.
The fraction of sensitization among lung transplant recipients in a transplant center in Japan.
复制标题
日本移植中心肺移植受者的致敏分数。
DOI：
10.1186/s12890-020-01299-0
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发表时间：
2020-10-02
影响因子：
3.1
通讯作者：
Okada Y
中科院分区：
文献类型：
--
作者：
Kumata S;Hirama T;Watanabe Y;Oishi H;Niikawa H;Akiba M;Tikkanen J;Okada Y
抗人类白细胞抗原（HLA）抗体检测于2018年获得日本政府批准。因此，没有关于日本肺移植（LTX）患者HLA致敏性的纵向数据。因此，我们开始在年度随访期间测量所有LTX患者的抗HLA抗体，以表征日本人群的致敏状态。该横断面研究针对2000年1月至2020年1月在东北大学医院（TUH）接受移植的连续LTX受体进行。采用群体反应试验（PRA）和供者特异性抗体（DSA）对受者血清进行抗HLA抗体筛查。在93例LTX受者中审查了致敏性，显示23例阳性（24.7%）和70例阴性（75.3%）PRA。在近期移植（60.9%（14/23），LTX后≤5年）中发现的致敏受体多于较早移植（17.4%（4/23），5-10年或21.7%（5/23），LTX后≥10年）（p = 0.04）。行DSA者更少（5.4%，5/93），其中4/5（80%）为近期移植。我们人群中PRA阳性LTX接受者的比例低于美国和欧洲以前的报告。在最近的移植中发现了比老年队列更多的致敏LTR，并且DSA主要在最近的接受者中确定。由于一些限制，目前尚不清楚致敏是否与CLAD的发展或生存有关，但这项研究将是未来在日本人群中进行抗HLA抗体研究的基础。
Anti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all our LTX patients during their annual follow-up to characterize the sensitization status in the Japanese population. The cross-sectional study was conducted for consecutive LTX recipients who underwent transplantation from January 2000 to January 2020 at Tohoku University Hospital (TUH). The serum from the recipients was screened for anti-HLA antibody with the panel-reactive assay (PRA) and the donor-specific antibodies (DSA). Sensitization was reviewed in 93 LTX recipients, showing 23 positive (24.7%) and 70 negative (75.3%) PRA. More sensitized recipients were found in recent transplantations (60.9% (14/23), ≤5 years post LTX) than in older transplantations (17.4% (4/23), 5–10 years or 21.7% (5/23), ≥10 years post LTX) (p = 0.04). Even fewer recipients had DSA (5.4%, 5/93), among whom 4/5 (80%) were recently transplanted. The rate of PRA positive LTX recipients in our population was lower compared with those in previous reports from US and Europe. More sensitized LTRs were found in recent transplantations than the older cohort, and DSA was identified primarily in the recent recipients. Due to several limitations, it is still unclear whether the sensitization would be related the development of CLAD or survival, yet this study would be fundamental to the future anti-HLA body study in Japanese population.
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影响因子：
9.8
作者：
Yamaguchi-Kabata, Yumi;Nakazono, Kazuyuki;Kamatani, Naoyuki
通讯作者：
Kamatani, Naoyuki
影响因子：
8.8
作者：
McCaughan, J. A.;Battle, R. K.;Tinckam, K. J.
通讯作者：
Tinckam, K. J.
影响因子：
2.1
作者：
Islam, Ana K.;Sinha, Neeraj;Gaber, A. Osama
通讯作者：
Gaber, A. Osama
影响因子：
2.1
作者：
Sullivan, Daniel;Ahn, Chul;Kaza, Vaidehi
通讯作者：
Kaza, Vaidehi
影响因子：
0.9
作者：
Hyun, J.;Park, K. D.;Park, M. H.
通讯作者：
Park, M. H.