Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain.
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain.
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DOI：
10.1038/ncomms8119
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发表时间：
2015-05-11
影响因子：
16.6
通讯作者：
Balloux, Francois
中科院分区：
文献类型：
--
作者：
Eldholm, Vegard;Monteserin, Johana;Rieux, Adrien;Lopez, Beatriz;Sobkowiak, Benjamin;Ritacco, Viviana;Balloux, Francois
耐药菌株的增加是遏制结核病（TB）大流行的重大挑战。然而，人们对化疗早期的耐药程度以及耐药菌株大规模传播成为主要公共卫生问题的情况知之甚少。在这里，我们重建了阿根廷耐多药结核病大规模爆发期间获得抗菌素耐药性的时间线。我们估计，爆发菌株的祖先在 1973 年左右就获得了对异烟肼、链霉素和利福平的耐药性，这表明多重耐药结核菌株持续传播了四十年。到 1979 年左右，该菌株对另外三种药物产生了额外的耐药性。我们的研究结果表明，具有广泛耐药性的结核分枝杆菌 (Mtb) 在检测到疫情爆发前 15 年就已经传播，比最早有记录的具有如此广泛耐药性的 Mtb 菌株在全球范围内的传播早了约 10 年。 人们对结核分枝杆菌多重耐药菌株的早期起源和进化知之甚少。在这里，作者对阿根廷结核病爆发的 252 个临床分离株进行了基因组和系统发育分析，并重建了抗生素耐药性获得的时间线。
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally. The early origin and evolution of multidrug resistant strains of Mycobacterium tuberculosis are poorly understood. Here, the authors perform genomic and phylogenetic analyses of 252 clinical isolates from a tuberculosis outbreak in Argentina and reconstruct the timeline of the acquisition of antibiotic resistance.
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影响因子：
30.8
作者：
Merker, Matthias;Blin, Camille;Wirth, Thierrv
通讯作者：
Wirth, Thierrv
影响因子：
30.8
作者：
Comas, Inaki;Borrell, Sonia;Roetzer, Andreas;Rose, Graham;Malla, Bijaya;Kato-Maeda, Midori;Galagan, James;Niemann, Stefan;Gagneux, Sebastien
通讯作者：
Gagneux, Sebastien
影响因子：
3.2
作者：
Miesel, L;Weisbrod, TR;Jacobs, WR
通讯作者：
Jacobs, WR
影响因子：
4.9
作者：
Bernard, Christine;Veziris, Nicolas;Aubry, Alexandra
通讯作者：
Aubry, Alexandra
影响因子：
7
作者：
Holden MT;Hsu LY;Kurt K;Weinert LA;Mather AE;Harris SR;Strommenger B;Layer F;Witte W;de Lencastre H;Skov R;Westh H;Zemlicková H;Coombs G;Kearns AM;Hill RL;Edgeworth J;Gould I;Gant V;Cooke J;Edwards GF;McAdam PR;Templeton KE;McCann A;Zhou Z;Castillo-Ramírez S;Feil EJ;Hudson LO;Enright MC;Balloux F;Aanensen DM;Spratt BG;Fitzgerald JR;Parkhill J;Achtman M;Bentley SD;Nübel U
通讯作者：
Nübel U