Interleukin-10 promotes pathological angiogenesis by regulating macrophage response to hypoxia during development.
Interleukin-10 promotes pathological angiogenesis by regulating macrophage response to hypoxia during development.
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白介素10通过调节发育过程中对缺氧的巨噬细胞反应来促进病理血管生成。
DOI：
10.1371/journal.pone.0003381
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Apte RS
中科院分区：
文献类型：
--
作者：
Dace DS;Khan AA;Kelly J;Apte RS
Aberrant angiogenesis in the eye is the most common cause of blindness. The current study examined the role of interleukin-10 (IL-10) in ischemia-induced pathological angiogenesis called neovascularization during postnatal development. IL-10 deficiency resulted in significantly reduced pathological retinal angiogenesis. In contrast to the choroicapillaris where IL-10 interferes with macrophage influx, IL-10 did not prevent anti-angiogenic macrophages from migrating to the retina in response to hypoxia. Instead, IL-10 promoted retinal angiogenesis by altering macrophage angiogenic function, as macrophages from wild-type mice demonstrated increased vascular endothelial growth factor (VEGF) and nitric oxide (NO) compared to IL-10 deficient macrophages. IL-10 appears to directly affect macrophage responsiveness to hypoxia, as macrophages responded to hypoxia with increased levels of IL-10 and STAT3 phosphorylation as opposed to IL-10 deficient macrophages. Also, IL-10 deficient macrophages inhibited the proliferation of vascular endothelial cells in response to hypoxia while wild-type macrophages failed to do so. These findings suggest that hypoxia guides macrophage behavior to a pro-angiogenic phenotype via IL-10 activated pathways.
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影响因子：
15.8
作者：
Apte, Rajendra S.;Richter, Jennifer;Herndon, John;Ferguson, Thomas A.
通讯作者：
Ferguson, Thomas A.
影响因子：
15.9
作者：
Sennlaub, F;Courtois, Y;Goureau, O
通讯作者：
Goureau, O
影响因子：
4.4
作者：
Mechoulam, H;Pierce, EA
通讯作者：
Pierce, EA
影响因子：
15.9
作者：
Christopherson, KS;Bredt, DS
通讯作者：
Bredt, DS
影响因子：
3.3
作者：
BERSE, B;BROWN, LF;SENGER, DR
通讯作者：
SENGER, DR