The Roles of TP53 and FGFR2 in Progress Made Treating Endometrial Cancer.
The Roles of TP53 and FGFR2 in Progress Made Treating Endometrial Cancer.
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DOI：
10.3390/diagnostics12071737
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发表时间：
2022-07-18
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子宫内膜癌（EC）的发病率和死亡率在世界范围内仍在上升。近年来，基于POLE突变状态、TP53和微卫星稳定性状态提出了一种新的肿瘤分层系统。该研究的目的是分析波兰人群中可能参与子宫内膜癌发生的大量基因。103例确诊为子宫内膜癌的白色女性患者入组研究。我们使用Hot Spot Illumina面板进行测序，并使用免疫组织化学进行微卫星稳定性。我们证实了TP53突变在高级EC进展中的关键作用和FGFR 2突变的重要作用。此外，我们的数据呈现了EC突变及其多态性的广阔前景。我们报道了FGFR 2突变和TP 53（高拷贝数）在高级别EC中的意义。我们的观察MSI的贡献是与其他研究。最后，我们看到一个强烈的需要实施的TCGA分类。
The morbidity and mortality caused by endometrial cancer (EC) is still rising worldwide. In recent years, a new system of tumor stratification has been proposed based on POLE-mutational status, TP53, and microsatellite stability status. The aim of the study was to analyze a vast panel on the genes potentially involved in the genesis of endometrial cancer in the Polish population. One hundred and three white female patients with confirmed endometrial cancer were enrolled on the study. We performed sequencing using the Hot Spot Illumina panel and microsatellite stability with immunohistochemistry. We confirmed a key role of the TP53 mutation in progress to high-grade EC and parallelly some role of FGFR2 mutation. Moreover, our data present a vast landscape of mutations in EC and their polymorphism. We reported the meaning of FGFR2 mutation and TP53 (high copy number) in high-grade ECs. Our observation in MSI contribution is comparable with other studies. Finally, we see a strong need for the implementation of the TCGA classification.
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