MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer
MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer
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MicroRNA-7 作为胰腺癌预后的潜在生物标志物
DOI：
10.1155/2020/2782101
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Gu Dian-na
中科院分区：
文献类型：
--
作者：
Ye Zhi-qiang;Zou Chang-lin;Chen Han-bin;Jiang Ming-jie;Mei Zhu;Gu Dian-na
microRNA在肿瘤进展中起关键作用。我们最近的研究表明，microRNA-7（miR-7）损害自噬衍生的葡萄糖池，以抑制胰腺癌进展中的糖酵解。然而，miR-7在胰腺癌的临床意义和化疗耐药性中的作用仍有待研究。本研究的目的是评估miR-7在胰腺癌患者中的表达，并评估其作为预后分子生物标志物的可能性。比较胰腺癌和健康个体、吉西他滨敏感和吉西他滨耐药患者血清中372种miRNAs的基于microRNA阵列的定量分析。我们发现miR-7对吉西他滨敏感的胰腺癌患者具有潜在的预测能力。然后，在胰腺组织微阵列和癌症基因组图谱（TCGA）数据集中验证结果，证明较低的miR-7表达与胰腺癌中更晚期的肿瘤分期和更差的预后相关。考克斯比例风险模型分析确定miR-7是预测生存期的独立变量。此外，利用胰腺癌组织微阵列和TCGA数据对miR-7的临床意义进行了机制探讨，提示miR-7可能通过干扰胰腺癌细胞的自噬和糖酵解而发挥作用。因此，本研究的结果提供了证据，microRNA-7的低表达可能有助于胰腺癌的肿瘤进展和不良预后。
MicroRNAs play critical roles in tumor progression. Our recent study has indicated that microRNA-7 (miR-7) impairs autophagy-derived pools of glucose to suppress the glycolysis in pancreatic cancer progression. However, the roles of miR-7 in clinical significance and chemoresistance of pancreatic cancer remain unexplored. The aim of this study was to assess the expression of miR-7 in patients with pancreatic cancer and to evaluate the possibility of its usage as a prognostic molecular biomarker. MicroRNA array-based quantification analysis of 372 miRNAs was compared in serum between pancreatic cancer and healthy individuals, gemcitabine-sensitive and gemcitabine-resistance patients. We identified miR-7 showed the potential predictive power for gemcitabine-sensitive patients with pancreatic cancer. Then, the results were validated in pancreatic tissue microarray and The Cancer Genome Atlas (TCGA) dataset, demonstrating that lower miR-7 expression was correlated with more advanced tumor stages and worse prognosis in pancreatic cancer. The Cox proportional-hazards model analysis identified miR-7 to be an independent variable for prediction of the survival. Furthermore, the mechanistic exploration suggested the clinical significance of miR-7 involved its interference effect on autophagy and glycolysis in pancreatic cancer using pancreatic cancer tissue microarrays and TCGA data. Therefore, the results of the present study provide evidences that low microRNA-7 expression may contribute to tumor progression and poor prognosis in pancreatic cancer.
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DOI：
10.1146/annurev.pathol.3.121806.154305
发表时间：
2021-08
期刊：
Annual review of pathology
影响因子：
--
作者：
A. Maitra;R. Hruban
通讯作者：
A. Maitra;R. Hruban
TM4SF1 促进胰腺癌体外和体内吉西他滨耐药
影响因子：
3.7
作者：
Cao J;Yang J;Ramachandran V;Arumugam T;Deng D;Li Z;Xu L;Logsdon CD
通讯作者：
Logsdon CD
影响因子：
9
作者：
Zhu，Xinzhe;Xiao，Zhiwen;Yu，Xianjun
通讯作者：
Yu，Xianjun
影响因子：
4.7
作者：
Lai, I-Lu;Chou, Chih-Chien;Chen, Ching-Shih
通讯作者：
Chen, Ching-Shih
miR-7 通过直接靶向胰腺癌中的 MAP3K9 来抑制肿瘤进展。
DOI：
10.1016/j.omtn.2018.08.012
发表时间：
2018-12-07
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Xia J;Cao T;Ma C;Shi Y;Sun Y;Wang ZP;Ma J
通讯作者：
Ma J