Clinical results of proton beam therapy for elderly patients with non-small cell lung cancer.
Clinical results of proton beam therapy for elderly patients with non-small cell lung cancer.
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DOI：
10.1186/s13014-018-0967-4
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发表时间：
2018-02-05
期刊：
影响因子：
--
通讯作者：
Nemoto K
中科院分区：
文献类型：
--
作者：
Ono T;Nakamura T;Yamaguchi H;Azami Y;Takayama K;Suzuki M;Wada H;Kikuchi Y;Murakami M;Nemoto K
本研究的目的是回顾性评价质子束治疗老年（≥80岁）非小细胞肺癌患者的疗效和安全性。从我们的数据库中回顾性招募了2009年1月至2015年期间诊断为T1-4 N 0 M0非小细胞肺癌并接受质子束治疗的患者。使用不良事件通用术语标准第4.0版评价毒性。35例患者，包括25例（71%）临床上不能手术的肺癌，进行质子束治疗。年龄中位数为82岁（范围：80-87岁），随访时间中位数为34个月（范围：10-72个月）。质子束治疗的中位剂量为80.0戈伊相对生物学有效性（RBE）（范围：60.0-80.0戈伊[RBE]），所有患者均完成治疗。所有患者随访至少23个月或直至死亡。3年总生存率为67.2%（可手术肺癌为90.0%，不可手术肺癌为58.2%）。3年局部控制率为86.5%。2例患者出现2级肺炎。2级肺炎的发生率与高肺V20（p = 0.030）、高平均肺剂量（p = 0.030）和低0.05戈伊剂量（RBE）下肺体积的比率（总肺体积减去至少0.05戈伊照射的肺体积[RBE]）显著相关（p = 0.030）。但是，没有3级或3级以上放射性肺炎病例。本研究提示质子束治疗老年非小细胞肺癌是可行的，可作为老年肺癌患者的治疗选择之一。
The purpose of the present study was to evaluate retrospectively the efficacy and safety of proton beam therapy for elderly patients (≥80 years of age) with non-small cell lung cancer. Patients diagnosed with T1–4 N0 M0 non-small cell lung cancer and treated with proton beam therapy between January 2009 and 2015 were recruited from our database retrospectively. Toxicity was evaluated using The Common Terminology Criteria for Adverse Events version 4.0. Thirty-five patients, including 25 (71%) with clinically inoperable lung cancer, were administered proton beam therapy. The median age was 82 years (range: 80–87 years), and the median follow-up time was 34 months (range: 10–72 months). The median dose of proton beam therapy was 80.0 Gy relative biological effectiveness (RBE) (range: 60.0–80.0 Gy [RBE]), and all patients completed the treatments. All patients were followed for at least 23 months or until their death. The 3-year overall survival rate was 67.2% (90.0% in patients with operable lung cancer, and 58.2% in those with inoperable lung cancer). The 3-year local control rate was 86.5%. Two patients presented with grade 2 pneumonitis. The occurrence rate of grade 2 pneumonitis was significantly correlated with a high lung V20 (p = 0.030), and a high mean lung dose (p = 0.030), and a low ratio of lung volume spared from 0.05 Gy (RBE) dose (total lung volume minus lung volume irradiated at least 0.05 Gy [RBE]) (p = 0.030). However, there were no cases of grade 3 or higher radiation pneumonitis. This study suggests that the proton beam therapy was feasible for elderly patients with non-small cell lung cancer and can be considered as one of the treatment choices for elderly patients with lung cancer.
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影响因子：
51.1
作者：
Chang, Joe Y.;Senan, Suresh;Paul, Marinus A.;Mehran, Reza J.;Louie, Alexander V.;Balter, Peter;Groen, Harry J. M.;McRae, Stephen E.;Widder, Joachim;Feng, Lei;van den Borne, Ben E. E. M.;Munsell, Mark F.;Hurkmans, Coen;Berry, Donald A.;van Werkhoven, Erik;Kresl, John J.;Dingemans, Anne-Marie;Dawood, Omar;Haasbeek, Cornelis J. A.;Carpenter, Larry S.;De Jaeger, Katrien;Komaki, Ritsuko;Slotman, Ben J.;Smit, Egbert F.;Roth, Jack A.
通讯作者：
Roth, Jack A.
影响因子：
4.6
作者：
NAKAHARA, K;MONDEN, Y;KAWASHIMA, Y
通讯作者：
KAWASHIMA, Y
DOI：
10.1016/j.ijrobp.2013.05.002
发表时间：
2013-08-01
影响因子：
7
作者：
Bush, David A.;Cheek, Gregory;Slater, Jerry D.
通讯作者：
Slater, Jerry D.
影响因子：
254.7
作者：
Torre, Lindsey A.;Bray, Freddie;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
2.9
作者：
Ma, Longfei;Xiang, Jiaqing
通讯作者：
Xiang, Jiaqing