Fibrinogen-to-albumin ratio predicts long-term outcomes for patients with ST-elevation myocardial infarction and multivessel disease: A prospective observational cohort study.
Fibrinogen-to-albumin ratio predicts long-term outcomes for patients with ST-elevation myocardial infarction and multivessel disease: A prospective observational cohort study.
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DOI：
10.3892/etm.2021.9896
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发表时间：
2021-05
影响因子：
2.7
通讯作者：
Cui GX
中科院分区：
文献类型：
--
作者：
Liu G;Fan CM;Guo H;Fan WN;Li ML;Cui GX
纤维蛋白原-白蛋白比值指数（FAR）是反映全身炎症水平的重要指标，与冠状动脉疾病的严重程度相关。然而，FAR在预测ST段抬高型心肌梗死（STEMI）和多支血管疾病患者的长期预后方面的效用仍有待确定。本研究共招募了424例诊断为STEMI和多支血管疾病的患者。他们接受了紧急经皮冠状动脉介入治疗，然后完成了主要（全因死亡率）和次要终点（主要不良心脏事件，包括MI、卒中、紧急血运重建和因心力衰竭再次住院）的随访。研究FAR与经皮冠状动脉介入治疗与紫杉醇和心脏手术之间的协同作用（SYNTAX）评分之间的相关性，同时采用受试者工作特征曲线分析来评估FAR预测长期结局的能力。绘制Kaplan-Meier生存曲线比较高、低FAR组的长期生存率。采用多因素考克斯回归分析评价主要和次要终点的危险因素。FAR与SYNTAX评分呈直线相关（y=0.022x+17.737; P=0.015）。此外，FAR是全因死亡的重要预测因子，其临界值为128.4（曲线下面积，0.832; P<0.001）。高FAR组和低FAR组在主要终点（P<0.001）和次要终点（P=0.001）的患者比例方面存在显著差异。结果表明，FAR是STEMI和多支血管病变患者全因死亡的独立危险因素（hazardratio，1.029; 95% CI：1.020-1.037; P<0.001）。总之，FAR是与STEMI相关的有价值的生物标志物，可能有助于预测STEMI和多支血管疾病患者的长期预后。
The fibrinogen-to-albumin ratio index (FAR) is a valuable tool reflecting the systemic inflammation level and associated with the severity of coronary artery disease. However, the utility of the FAR in predicting the long-term prognosis of patients with ST-elevation myocardial infarction (STEMI) and multivessel disease has remained to be determined. A total of 424 patients diagnosed with STEMI and multivessel disease were recruited for the present study. They were given emergent percutaneous coronary intervention treatment and then completed a follow-up for primary (all-cause mortality) and secondary endpoints (major adverse cardiac events, including MI, stroke, emergent revascularization and rehospitalization due to heart failure). The association between FAR and the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score was investigated, while receiver operating characteristic curve analysis was adopted to assess the ability of the FAR to predict long-term outcomes. The long-term survival of high and low FAR groups was compared by drawing Kaplan-Meier survival curves. Multivariate Cox regression analysis was adopted to evaluate the risk factors of primary and secondary endpoints. The FAR was revealed to have a linear correlation with the SYNTAX score (y=0.022x+17.737; P=0.015). Furthermore, the FAR was a significant predictor of all-cause death with a cut-off value of 128.4 (area under the curve, 0.832; P<0.001). A significant difference was determined between the high FAR group and the low FAR group in terms of the proportion of patients with the primary endpoint (P<0.001) and secondary endpoint (P=0.001). It was demonstrated that the FAR was an independent risk factor for all-cause death of patients with STEMI and multivessel disease (hazard ratio, 1.029; 95% CI: 1.020-1.037; P<0.001). In summary, the FAR is a valuable biomarker associated with STEMI and may be useful in the prediction of the long-term prognosis of patients with STEMI and multivessel disease.
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