The Remnant Lipoprotein Hypothesis of Diabetes-Associated Cardiovascular Disease.
The Remnant Lipoprotein Hypothesis of Diabetes-Associated Cardiovascular Disease.
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DOI：
10.1161/atvbaha.122.317163
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发表时间：
2022-07
影响因子：
8.7
通讯作者：
Bornfeldt, Karin E.
中科院分区：
文献类型：
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作者：
Bornfeldt, Karin E.
1型糖尿病（T1DM）和2型糖尿病（T2DM）均与动脉粥样硬化性心血管疾病风险增加相关。基于人类优先或床旁到长凳方法的研究为这种风险增加背后的可能机制提供了新的见解。虽然这两种形式的糖尿病都与高血糖症有关，但越来越清楚的是，脂蛋白代谢的改变在预测糖尿病患者的心血管疾病风险方面也起着关键作用。本文回顾了最近的研究结果表明，循环残余脂蛋白水平的增加可能是糖尿病和心血管疾病之间的一个缺失环节。虽然糖尿病相关的心血管疾病风险在本质上是多因素的，但这些发现表明，我们应该加大力度评估残余脂蛋白或控制其代谢的蛋白质是否是糖尿病患者发生心血管疾病的生物标志物，以及减少残余脂蛋白是否会预防糖尿病相关的心血管疾病风险增加。
Both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are associated with an increased risk of atherosclerotic cardiovascular disease. Research based on human-first or bedside-to-bench approaches has provided new insights into likely mechanisms behind this increased risk. Although both forms of diabetes are associated with hyperglycemia, it is becoming increasingly clear that altered lipoprotein metabolism also plays a critical role in predicting cardiovascular disease risk in people with diabetes. This review examines recent findings indicating that increased levels of circulating remnant lipoproteins could be a missing link between diabetes and cardiovascular disease. Although cardiovascular disease risk associated with diabetes is clearly multifactorial in nature, these findings suggest that we should increase efforts in evaluating whether remnant lipoproteins or the proteins that govern their metabolism are biomarkers of incident cardiovascular disease in people living with diabetes, and whether reducing remnant lipoproteins will prevent the increased cardiovascular disease risk associated with diabetes.
DOI：
10.1084/jem.100.4.371
发表时间：
1954-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
DUFF GL;BRECHIN DJ;FINKELSTEIN WE
通讯作者：
FINKELSTEIN WE