The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit. IV. The effect of insulin therapy on the inhibition of atherosclerosis in the alloxan-diabetic rabbit.
The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit. IV. The effect of insulin therapy on the inhibition of atherosclerosis in the alloxan-diabetic rabbit.
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DOI：
10.1084/jem.100.4.371
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发表时间：
1954-10-01
期刊：
影响因子：
--
通讯作者：
FINKELSTEIN WE
中科院分区：
文献类型：
--
作者：
DUFF GL;BRECHIN DJ;FINKELSTEIN WE
进行实验以确定先前证明的对喂食胆固醇的四氧嘧啶糖尿病兔子实验性主动脉粥样硬化发展的抑制是否是由于四氧嘧啶本身的注射或由于四氧嘧啶产生的糖尿病状态的存在。已确定，通过用胰岛素治疗糖尿病状态，可以改善糖尿病状态并消除抑制作用。因此得出的结论是，抑制现象不是由于注射四氧嘧啶本身引起的，而是与一种或多种表征兔子四氧嘧啶糖尿病状态的因素有关，并且这些因素可通过胰岛素治疗逆转。实验过程表明，无论饮食中是否添加植物油，对胆固醇喂养的糖尿病兔的抑制作用都是明显的。先前报道的糖尿病动物的代谢异常得到了证实。已经确定，用胰岛素对饲喂胆固醇的糖尿病动物进行适当的治疗将使所有代谢异常（包括血清脂质的异常）与饲喂胆固醇的非糖尿病兔子中观察到的代谢异常相当接近。
Experiments were undertaken to ascertain whether the previously demonstrated inhibition of the development of experimental aortic atherosclerosis in alloxan-diabetic rabbits fed cholesterol was due to the injection of alloxan per se or to the existence of the diabetic state produced by alloxan. It was established that, by treating the diabetic state with insulin, the diabetic state could be ameliorated and the inhibitory effect obviated. It was therefore concluded that the inhibitory phenomenon was not due to the injection of alloxan per se but that it was associated with one or more factors that characterize the alloxan diabetic state in the rabbit and that are reversible by insulin therapy. In the course of the experiment it was demonstrated that the inhibitory effect was apparent in cholesterol-fed diabetic rabbits whether or not their diet was supplemented with vegetable oil. The previously reported metabolic abnormalities of the diabetic animals were confirmed. It was established that suitable treatment of the cholesterol-fed diabetic animals with insulin would bring all the metabolic aberrations, including those of the serum lipids, into reasonably close correspondence with those observed in non-diabetic rabbits fed cholesterol.
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DOI：
10.1084/jem.99.2.119
发表时间：
1954-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
COOK DL;MILLS LM;GREEN DM
通讯作者：
GREEN DM
影响因子：
15.3
作者：
DUFF, G L;McMILLAN, G C
通讯作者：
McMILLAN, G C
DOI：
10.3181/00379727-74-18033
发表时间：
1950-01-01
影响因子：
--
作者：
FIRSTBROOK, JB
通讯作者：
FIRSTBROOK, JB
影响因子：
56.9
作者：
FIRSTBROOK, JB
通讯作者：
FIRSTBROOK, JB
DOI：
10.1084/jem.99.3.261
发表时间：
1954-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
McMILLAN GC;WHITESIDE JH;DUFF GL
通讯作者：
DUFF GL