Why are nutritionally stunted children at increased risk of obesity? Studies of metabolic rate and fat oxidation in shantytown children from São Paulo, Brazil.
Why are nutritionally stunted children at increased risk of obesity? Studies of metabolic rate and fat oxidation in shantytown children from São Paulo, Brazil.
复制标题
为什么营养不良的儿童肥胖的风险增加？对巴西圣保罗棚户区儿童的代谢率和脂肪氧化的研究。
DOI：
10.1093/ajcn/72.3.702
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
S. Roberts
中科院分区：
文献类型：
--
作者：
D. Hoffman;A. Sawaya;I. Verreschi;K. Tucker;S. Roberts
背景
先前的研究表明，营养不良的儿童可能会增加肥胖的风险，但人们对潜在的潜在机制知之甚少。
目标
我们试图检验以下假设：相对于非发育迟缓儿童，发育迟缓儿童的代谢率较低且脂肪氧化受损。
设计
研究对象是来自巴西圣保罗棚户区的 58 名 8 至 11 岁青春期前男孩和女孩。 28 人发育迟缓（年龄别身高 z 得分 <-1.5），30 人身高别体重相似，但身高正常（年龄别身高 z 得分 >-1.5）。两组儿童的父母具有相同的身高和体重指数值。在一项为期 3 天的常驻研究中，使用间接量热法测量空腹和餐后能量消耗、呼吸商 (RQ) 和底物氧化，其中提供所有食物，并使用双能 X 射线吸收测定法测量身体成分。
结果
与对照儿童相比，发育迟缓儿童相对于身体成分的静息能量消耗正常（分别为 4559 +/- 90 和 4755 +/- 86 kJ/d；P：= 0.14），并且餐后产热正常（分别为膳食负荷的 2.4 +/- 0.3% 和 2.0 +/- 0.3%；P：= 0.42）。然而，发育不良组的空腹 RQ 显着较高（0.92 +/- 0.009 与 0.89 +/- 0.007 相比；P：= 0.04），因此，空腹脂肪氧化显着较低（能量消耗的 25 +/- 2% 与 34 +/- 2% 相比；P：< 0.01）。
结论
儿童营养发育迟缓与脂肪氧化受损有关，脂肪氧化受损是其他高危人群肥胖的预测因素。这一发现可能有助于解释最近发展中国家发育不良的成年人和青少年身体脂肪增加和肥胖流行的原因。
BACKGROUND
Previous research suggested that nutritionally stunted children may have increased risk of obesity, but little is known about potential underlying mechanisms.
OBJECTIVE
We sought to test the hypothesis that stunted children have a low metabolic rate and impaired fat oxidation relative to nonstunted children.
DESIGN
The subjects were 58 prepubertal boys and girls aged 8-11 y from the shantytowns of São Paulo, Brazil. Twenty-eight were stunted (height-for-age z score <-1.5) and 30 had similar weight-for-height but normal height (height-for-age z score >-1.5). Parents of children in the 2 groups had equivalent height and body mass index values. Fasting and postprandial energy expenditure, respiratory quotient (RQ), and substrate oxidation were measured with indirect calorimetry in a 3-d resident study in which all food was provided and body composition was measured with dual-energy X-ray absorptiometry.
RESULTS
Stunted children had normal resting energy expenditure relative to body composition compared with control children (4559 +/- 90 and 4755 +/- 86 kJ/d, respectively; P: = 0.14) and had normal postprandial thermogenesis (2.4 +/- 0.3% and 2.0 +/- 0.3% of meal load, respectively; P: = 0.42). However, fasting RQ was significantly higher in the stunted group (0.92 +/- 0.009 compared with 0.89 +/- 0.007; P: = 0.04) and consequently, fasting fat oxidation was significantly lower (25 +/- 2% compared with 34 +/- 2% of energy expenditure; P: < 0.01).
CONCLUSIONS
Childhood nutritional stunting is associated with impaired fat oxidation, a factor that predicted obesity in other at-risk populations. This finding may help explain recent increases in body fatness and the prevalence of obesity among stunted adults and adolescents in developing countries.
高脂肪和低脂肪饮食对自愿能量摄入和底物氧化的影响：对同卵双胞胎的研究，其饮食与能量密度、纤维和适口性相匹配。
DOI：
10.1093/ajcn/66.6.1332
发表时间：
1997
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Saltzman,E;Dallal,GE;Roberts,SB
通讯作者：
Roberts,SB
20 周耐力训练导致静息代谢率的变化：HERITAGE 家族研究。
DOI：
10.1093/ajcn/68.1.66
发表时间：
1998
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Wilmore,JH;Stanforth,PR;Hudspeth,LA;Gagnon,J;Daw,EW;Leon,AS;Rao,DC;Skinner,JS;Bouchard,C
通讯作者：
Bouchard,C
影响因子：
7.1
作者：
Pintauro, SJ;Nagy, TR;Goran, MI
通讯作者：
Goran, MI