Osteopontin/secreted phosphoprotein-1 harnesses glial-, immune-, and neuronal cell ligand-receptor interactions to sense and regulate acute and chronic neuroinflammation.
Osteopontin/secreted phosphoprotein-1 harnesses glial-, immune-, and neuronal cell ligand-receptor interactions to sense and regulate acute and chronic neuroinflammation.
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DOI：
10.1111/imr.13081
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发表时间：
2022-10
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
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作者：
骨桥蛋白（OPN）也以其官方基因名称分泌型磷蛋白-1（SPP 1）而闻名，是一种迷人的多功能蛋白质，在许多细胞类型中表达，不仅在细胞间通讯中发挥作用，而且在细胞外基质（ECM）中也发挥作用。OPN/SPP 1具有细胞因子、趋化因子和信号转导功能，其模块化结构基序为整合素和CD 44变体受体提供相互作用表面。在人类中，有三种实验验证的OPN/SPP 1的剪接变体，并且CD 44的十个外显子也以细胞/组织特异性方式交替调味，尽管对中枢神经系统（CNS）中如何调控知之甚少。在OPN/SPP 1发挥功能的细胞和组织中，磷酸化、糖基化和特定蛋白酶的局部切割的翻译后修饰提供了额外的特异性层。然而，前者使得阐明OPN/SPP 1功能的确切分子机制更加复杂。OPN/SPP 1结构的灵活性及其与整合素的接合能够在由内向外和由外向内的方向上传递信号，这可能是OPN/SPP 1可以作为炎症和持续组织损伤的早期检测器的原因，以响应癌症，中风，创伤性脑损伤，病原性感染和神经变性，损害组织稳态的过程。本文将重点介绍目前已知的OPN/SPP 1在大脑中的功能。
Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1 (SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that functions not only in intercellular communication, but also in the extracellular matrix (ECM). OPN/SPP1 possesses cytokine, chemokine, and signal transduction functions by virtue of modular structural motifs that provide interaction surfaces for integrins and CD44‐variant receptors. In humans, there are three experimentally verified splice variants of OPN/SPP1 and CD44’s ten exons are also alternatively spiced in a cell/tissue‐specific manner, although very little is known about how this is regulated in the central nervous system (CNS). Post‐translational modifications of phosphorylation, glycosylation, and localized cleavage by specific proteases in the cells and tissues where OPN/SPP1 functions, provides additional layers of specificity. However, the former make elucidating the exact molecular mechanisms of OPN/SPP1 function more complex. Flexibility in OPN/SPP1 structure and its engagement with integrins having the ability to transmit signals in inside‐out and outside‐in direction, is likely why OPN/SPP1 can serve as an early detector of inflammation and ongoing tissue damage in response to cancer, stroke, traumatic brain injury, pathogenic infection, and neurodegeneration, processes that impair tissue homeostasis. This review will focus on what is currently known about OPN/SPP1 function in the brain.
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DOI：
10.1007/s11481-020-09914-x
发表时间：
2021-06
期刊：
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
影响因子：
--
作者：
Müller-Oehring EM;Hong JY;Hughes RL;Kwon D;Brontë-Stewart HM;Poston KL;Schulte T
通讯作者：
Schulte T
影响因子：
15.1
作者：
Boska MD;Dash PK;Knibbe J;Epstein AA;Akhter SP;Fields N;High R;Makarov E;Bonasera S;Gelbard HA;Poluektova LY;Gendelman HE;Gorantla S
通讯作者：
Gorantla S
影响因子：
2
作者：
Calkins, Hugh;Hindricks, Gerhard;Yamane, Teiichi
通讯作者：
Yamane, Teiichi
影响因子：
4.8
作者：
Campbell, Grant R.;Bruckman, Rachel S.;Spector, Stephen A.
通讯作者：
Spector, Stephen A.
影响因子：
9.3
作者：
Angel Abellanas, Miguel;Zamarbide, Marta;Aymerich, Maria S.
通讯作者：
Aymerich, Maria S.