Alterations of Brain Signal Oscillations in Older Individuals with HIV Infection and Parkinson's Disease.
Alterations of Brain Signal Oscillations in Older Individuals with HIV Infection and Parkinson's Disease.
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HIV感染和帕金森病老年人脑信号振荡的改变
DOI：
10.1007/s11481-020-09914-x
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Schulte T
中科院分区：
文献类型：
--
作者：
Müller-Oehring EM;Hong JY;Hughes RL;Kwon D;Brontë-Stewart HM;Poston KL;Schulte T
在人类免疫缺陷病毒（HIV）流行30多年后，由于抗逆转录病毒疗法的进步，HIV患者正在老化。随着免疫衰老和富含多巴胺的基底神经节区域对HIV相关损伤的易感性，老年HIV患者可能表现出与帕金森病（PD）患者相似的神经功能缺陷。我们检查了30名老年HIV感染者、33名老年健康对照者和36名PD患者的BOLD信号不同频带的低频波动（ALFF）幅度。参与者进行了静息态功能磁共振成像，神经心理学测试，和临床运动examin. HIV患者主要表现出异常的皮质ALFF减少前额叶振幅和增强感觉运动和下颞振幅。HIV和PD组的额叶低激活是重叠的，与对照组不同。与其他组相比，PD患者进一步表现出苍白球振幅降低。在HIV组中，较低的苍白球振幅与较低的CD 4+最低点和CD 4 + T细胞计数相关。ALFF动力学的异常在很大程度上与HIV和PD组的认知和运动功能相关。皮质下-皮质回路中神经功能频率动力学的破坏可能有助于认知和运动功能障碍的发展，并可作为监测免疫衰老疾病进展的生物标志物。
More than 30 years after the human immunodeficiency virus (HIV) epidemic, HIV patients are now aging due to the advances of antiretroviral therapy. With immunosenescence and the susceptibility of dopamine-rich basal ganglia regions to HIV-related injury, older HIV patients may show neurofunctional deficits similar to patients with Parkinson’s disease (PD). We examined the amplitudes of low frequency fluctuations (ALFF) across different frequency bands of the BOLD signal in 30 older HIV-infected individuals, 33 older healthy controls, and 36 PD patients. Participants underwent resting-state fMRI, neuropsychological testing, and a clinical motor exam. HIV patients mainly showed abnormalities in cortical ALFF with reduced prefrontal amplitudes and enhanced sensorimotor and inferior temporal amplitudes. Frontal hypoactivation was overlapping for HIV and PD groups and different from controls. PD patients further exhibited reduced pallidum amplitudes compared to the other groups. In the HIV group, lower pallidum amplitudes were associated with lower CD4+ nadir and CD4+ T cell counts. Abnormalities in ALFF dynamics were largely associated with cognitive and motor functioning in HIV and PD groups. The disruption of neurofunctional frequency dynamics in subcortical-cortical circuits could contribute to the development of cognitive and motor dysfunction and serve as a biomarker for monitoring disease progression with immunosenescence.
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DOI：
10.1097/qad.0000000000001178
发表时间：
2016-10-23
期刊：
AIDS (London, England)
影响因子：
--
作者：
Ferguson D;Clarke S;Berry N;Almond N
通讯作者：
Almond N
影响因子：
3.2
作者：
Becker, James T.;Sanders, Joanne;Madsen, Sarah K.;Ragin, Ann;Kingsley, Lawrence;Maruca, Victoria;Cohen, Bruce;Goodkin, Karl;Martin, Eileen;Miller, Eric N.;Sacktor, Ned;Alger, Jeffery R.;Barker, Peter B.;Saharan, Priyanka;Carmichael, Owen T.;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
9.9
作者：
Grant, Igor;Franklin, Donald R., Jr.;Heaton, Robert K.
通讯作者：
Heaton, Robert K.
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
HIV 功能 MRI 综述：衰老和药物治疗的影响。
影响因子：
3.2
作者：
Hakkers CS;Arends JE;Barth RE;Du Plessis S;Hoepelman AI;Vink M
通讯作者：
Vink M