Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes.
Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes.
复制标题
DOI：
10.3389/fimmu.2023.1151422
复制
发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然囊性纤维化（CF）肺病的特征在于持续的炎症和感染，并且慢性炎性疾病通常伴有自身免疫，但CF中的自身免疫反应性尚未深入研究。在这项工作中，我们进行了一个公正的方法来探讨系统性自身抗体库CF使用自身抗体微阵列。我们的研究结果显示，与对照组相比，CF（PwCF）患者血液中的几种新的自身抗体水平更高。其中一些是靶向中性粒细胞组分的伊加自身抗体或与CF中嗜中性粒细胞介导的组织损伤相关的自身抗原。我们还发现，具有较高系统性IgM自身抗体水平的CF患者具有较低的S。金黄色葡萄球菌感染。另一方面，S.金黄色葡萄球菌感染的PwCF与肺部疾病的严重程度相关。与非糖尿病PwCF相比，糖尿病PwCF在其循环中具有显著更高水平的伊加自身抗体，并且其几种IgM自身抗体与更严重的肺部疾病相关。相反，在非糖尿病PwCF血液伊加自身抗体水平与肺部疾病。我们还鉴定了CF中与铜绿假单胞菌气道感染相关的其他自身抗体。总之，我们已经确定了几个新的自身抗体和自身抗体的签名与CF的特定临床特征的关联。
While cystic fibrosis (CF) lung disease is characterized by persistent inflammation and infections and chronic inflammatory diseases are often accompanied by autoimmunity, autoimmune reactivity in CF has not been studied in depth. In this work we undertook an unbiased approach to explore the systemic autoantibody repertoire in CF using autoantibody microarrays. Our results show higher levels of several new autoantibodies in the blood of people with CF (PwCF) compared to control subjects. Some of these are IgA autoantibodies targeting neutrophil components or autoantigens linked to neutrophil-mediated tissue damage in CF. We also found that people with CF with higher systemic IgM autoantibody levels have lower prevalence of S. aureus infection. On the other hand, IgM autoantibody levels in S. aureus-infected PwCF correlate with lung disease severity. Diabetic PwCF have significantly higher levels of IgA autoantibodies in their circulation compared to nondiabetic PwCF and several of their IgM autoantibodies associate with worse lung disease. In contrast, in nondiabetic PwCF blood levels of IgA autoantibodies correlate with lung disease. We have also identified other autoantibodies in CF that associate with P. aeruginosa airway infection. In summary, we have identified several new autoantibodies and associations of autoantibody signatures with specific clinical features in CF.
影响因子：
5.8
作者：
Chen H;Yang H;Cheng QX;Ge YP;Peng QL;Zhang YM;Cheng GH;Wang GC;Lu X
通讯作者：
Lu X
影响因子：
5.2
作者：
Theprungsirikul, J.;Skopelja-Gardner, S.;Meagher, R. E.;Clancy, J. P.;Zemanick, E. T.;Ashare, A.;Rigby, W. F. C.
通讯作者：
Rigby, W. F. C.
影响因子：
--
作者：
Chen, Qiuhe;Qian, Long
通讯作者：
Qian, Long