Clinical Features of Dermatomyositis/Polymyositis with Anti-MDA5 Antibody Positivity.
Clinical Features of Dermatomyositis/Polymyositis with Anti-MDA5 Antibody Positivity.
复制标题
DOI：
10.1155/2022/7102480
复制
发表时间：
2022
影响因子：
--
通讯作者：
Qian, Long
中科院分区：
文献类型：
--
作者：
Chen, Qiuhe;Qian, Long
本文通过分析抗MDA 5抗体阳性的多发性肌炎（PM）和皮肌炎（DM）PM/DM患者的临床特征、实验室检查结果和1年生存率，探讨抗MDA 5抗体阳性PM/DM患者的临床和实验室检查特点。进一步探讨抗MDA 5抗体阳性对PM/DM患者预后的影响。根据抗-MDA 5抗体检测结果，抗-MDA 5抗体阳性者18例为阳性组，抗-MDA 5抗体阴性者46例为阴性组。收集两组患者的临床表现、实验室检查、治疗方案和预后危险因素。采用卡方检验、Mann-Whitney法、Fisher检验、t检验、Kaplan-Meier法和Log-rank检验进行统计学分析。抗MDA 5抗体阳性多见于DM/CADM患者。两组患者年龄、性别比差异无统计学意义，阳性组血沉、铁蛋白、肌酸激酶水平与阴性组比较差异有统计学意义。临床上，阳性组更容易出现关节痛、皮疹和间质性肺炎。
This paper aims to investigate the clinical and laboratory test characteristics of patients with anti-MDA5 antibody-positive PM/DM by analyzing the clinical characteristics, laboratory test results, and 1-year survival rate of patients with anti-MDA5 antibody-positive PM/DM in polymyositis (PM) and dermatomyositis (DM). To further investigate the impact of positive anti-MDA5 antibodies on the prognosis of PM/DM patients. According to the anti-MDA5 antibody test results, 18 cases with positive anti-MDA5 antibodies were in the positive group and 46 cases with negative anti-MDA5 antibodies were in the negative group. The clinical manifestations, laboratory tests, treatment protocols, and prognostic risk factors were collected for both groups. The chi-square test, Mann–Whitney method, Fisher test, t-test, Kaplan–Meier method, and Log-rank test were used for statistical analysis. Anti-MDA5 antibody positivity was more common in patients with DM/CADM. With no statistically significant differences in age and sex ratio between the two groups, The differences in erythrocyte sedimentation rate (ESR), ferritin (Fer), and creatine kinase (CK) levels in the positive group were statistically significant compared with the negative group. Clinically, the positive group was more prone to arthralgia, skin rash, and interstitial pneumonia.
登录
查看更多内容
影响因子：
0.7
作者：
Kishaba, Tomoo;McGill, Rita;Yamashiro, Shin
通讯作者：
Yamashiro, Shin
影响因子：
2.7
作者：
Mercan, Ridvan;Bitik, Berivan;Goker, Berna
通讯作者：
Goker, Berna
影响因子：
2.2
作者：
Fujiki, Youhei;Kotani, Takuya;Makino, Shigeki
通讯作者：
Makino, Shigeki
影响因子：
3.7
作者：
Ha YJ;Hur J;Go DJ;Kang EH;Park JK;Lee EY;Shin K;Lee EB;Song YW;Lee YJ
通讯作者：
Lee YJ
影响因子：
4.2
作者：
Kisacik, Bunyamin;Tufan, Abdurrahman;Calguneri, Meral
通讯作者：
Calguneri, Meral