HIV/TB co-infection in mainland China: a meta-analysis.

HIV/TB co-infection in mainland China: a meta-analysis.
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DOI:
10.1371/journal.pone.0010736
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发表时间:
2010-05-20
期刊:
影响因子:
3.7
通讯作者:
Jin Q
Jin Q
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Gao L;Zhou F;Li X;Jin Q

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在世界许多地区,特别是在发展中国家,结核病和艾滋病毒的共同流行是一个重大的公共卫生问题。我们的目的是总结中国大陆地区结核病和艾滋病合并感染的流行情况,采用基于已发表文章的系统综述的荟萃分析。我们系统地回顾了来自MEDLINE和中国生物医学文献数据库的已发表的研究,这些研究涉及到2010年4月15日之前结核病患者中HIV感染的流行情况以及HIV/AIDS人群中结核病的流行情况,并使用meta分析对估计结果进行了定量总结。本综述共纳入29项研究,结果一致。中国大陆结核病患者HIV总感染率为0.9%(0.6%-1.4%),是HIV筛查的潜在目标人群。艾滋病毒/艾滋病人群中结核病患病率为7.2%(4.2%-12.3%),但当分析仅限于艾滋病患者时,这一数字要高得多(22.8%)。在以医院为基础的研究中,男性的患病率明显更高。我们的分析表明,中国HIV/TB合并感染的患病率值得特别关注,在HIV/AIDS人群中进行TB筛查应得到更多的重视,这将更有助于两种疾病的治疗。
TB and HIV co-epidemic is a major public health problem in many parts of the world, particularly in developing counties. We aimed to summarize the prevalence of TB and HIV co-infection in mainland China, using meta-analysis based on systematic review of published articles. We systematically reviewed published studies, from the MEDLINE and Chinese BioMedical Literature Databases, on the prevalence of HIV infection among TB patients and on the prevalence of TB among HIV/AIDS population until 15 April 2010, and quantitatively summarized the estimates using meta-analysis. In total, 29 studies were included in this review, with consistently homogeneous results. TB patients, for whom the summary prevalence of HIV infection was 0.9% (0.6%–1.4%) in mainland China, were found to be a potential target population for HIV screening. The prevalence of TB among HIV/AIDS population was 7.2% (4.2%–12.3%), but this was much higher when the analyses were restricted to AIDS patients (22.8%). Significantly higher prevalence was observed for males and hospital-based studies. Our analyses indicated that the prevalence of HIV/TB co-infection in China deserves special attention, screening of TB among HIV/AIDS populations should be attached more importance, which would be much more helpful for treatment of both diseases.
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