Biodegradation and Biotransformation of Indole: Advances and Perspectives.
Biodegradation and Biotransformation of Indole: Advances and Perspectives.
复制标题
吲哚的生物降解和生物转化：进展和前景。
DOI：
10.3389/fmicb.2018.02625
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发表时间：
2018
影响因子：
5.2
通讯作者：
Qu Y
中科院分区：
文献类型：
--
作者：
Ma Q;Zhang X;Qu Y
吲哚一直被认为是工农业废水中典型的n -杂环芳香族污染物，近年来被发现是一种具有广泛环境分布的多功能信号分子。由于吲哚在细菌生理、发病机制、动物行为和人类疾病等方面的重要作用，对其的研究呈指数级增长。从环境生物修复和生物学研究的角度来看，研究吲哚的代谢和命运对实现环境治理和阐明其生物学功能都具有重要意义。在许多细菌中，色氨酸可以通过色氨酸酶产生吲哚。同时，各种细菌菌株都获得了转化和降解吲哚的能力。吲哚降解的特性和途径已经被研究了一个世纪，吲哚有氧降解的功能基因也在最近被发现。有趣的是，许多加氧酶已经被证明能够将吲哚氧化成靛蓝，这一具有历史意义和激励意义的生物应用案例几十年来一直吸引着人们的密切关注。本文系统综述了吲哚产生、生物降解和生物转化的细菌、酶和途径，并对吲哚-微生物相互作用的未来研究进行了展望。
Indole is long regarded as a typical N-heterocyclic aromatic pollutant in industrial and agricultural wastewater, and recently it has been identified as a versatile signaling molecule with wide environmental distributions. An exponentially growing number of researches have been reported on indole due to its significant roles in bacterial physiology, pathogenesis, animal behavior and human diseases. From the viewpoint of both environmental bioremediation and biological studies, the researches on metabolism and fates of indole are important to realize environmental treatment and illuminate its biological function. Indole can be produced from tryptophan by tryptophanase in many bacterial species. Meanwhile, various bacterial strains have obtained the ability to transform and degrade indole. The characteristics and pathways for indole degradation have been investigated for a century, and the functional genes for indole aerobic degradation have also been uncovered recently. Interestingly, many oxygenases have proven to be able to oxidize indole to indigo, and this historic and motivating case for biological applications has attracted intensive attention for decades. Herein, the bacteria, enzymes and pathways for indole production, biodegradation and biotransformation are systematically summarized, and the future researches on indole-microbe interactions are also prospected.
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影响因子：
4.8
作者：
Bjerregaard-Andersen, Kaare;Sommer, Theis;Morth, J. Preben
通讯作者：
Morth, J. Preben
影响因子：
5
作者：
Doukyu, N;Toyoda, K;Aono, R
通讯作者：
Aono, R
影响因子：
3.4
作者：
Berry, A;Dodge, TC;Weyler, W
通讯作者：
Weyler, W
DOI：
10.1016/s0301-6226(01)00189-0
发表时间：
2001-10-01
期刊：
LIVESTOCK PRODUCTION SCIENCE
影响因子：
--
作者：
Deslandes, B;Gariépy, C;Houde, A
通讯作者：
Houde, A
影响因子：
2.7
作者：
Ameria, Sisi Patricia Lolita;Jung, Hye Sook;Lee, Jin Ho
通讯作者：
Lee, Jin Ho