Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms
Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms
复制标题
斑马鱼幼虫的功能性脑成像，用于表征通过一系列药理机制发挥作用的致癫痫化合物的作用
DOI：
--
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
C. Tyler
中科院分区：
文献类型：
--
作者：
M. Winter;J. Pinion;Anna Tochwin;A. Takesono;Jonathan S Ball;Piotr Grabowski;J. Metz;M. Trznadel;K. Tse;Will S Redfern;M. Hetheridge;M. Goodfellow;A. Randall;C. Tyler
使用斑马鱼幼体基因编码 Ca2+ 传感器的功能性脑成像正在开发中，用于研究癫痫发作和癫痫，作为啮齿动物模型的更合乎道德的替代方案。尽管如此，除了 GABAA 拮抗作用之外，关于药理学作用机制的数据很少。评估幼虫跨多种机制的反应性对于测试这种方法的转化能力以及评估其检测不良药物引起的癫痫发作和测试抗癫痫药物疗效的有效性至关重要。
Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacological mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug‐induced seizures and testing antiepileptic drug efficacy.
比较 MK-801 和苯环己哌啶对儿茶酚胺摄取和 NMDA 诱导的去甲肾上腺素释放的影响。
影响因子：
5
作者：
Snell,LD;Yi,SJ;Johnson,KM
通讯作者：
Johnson,KM
影响因子：
16.6
作者：
Carmen Diaz Verdugo;Sverre Myren-Svelstad;Ecem Aydın;Evelien Van Hoeymissen;Celine Deneubourg;Silke Vanderha
通讯作者：
Carmen Diaz Verdugo;Sverre Myren-Svelstad;Ecem Aydın;Evelien Van Hoeymissen;Celine Deneubourg;Silke Vanderha