The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan.
The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan.
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软壳乌龟和绿海龟的基因组草案对特定特定身体计划的发展和演变产生了见解。
DOI：
10.1038/ng.2615
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发表时间：
2013-06
期刊：
影响因子：
30.8
通讯作者：
Irie, Naoki
中科院分区：
文献类型：
--
作者：
Wang, Zhuo;Pascual-Anaya, Juan;Zadissa, Amonida;Li, Wenqi;Niimura, Yoshihito;Huang, Zhiyong;Li, Chunyi;White, Simon;Xiong, Zhiqiang;Fang, Dongming;Wang, Bo;Ming, Yao;Chen, Yan;Zheng, Yuan;Kuraku, Shigehiro;Pignatelli, Miguel;Herrero, Javier;Beal, Kathryn;Nozawa, Masafumi;Li, Qiye;Wang, Juan;Zhang, Hongyan;Yu, Lili;Shigenobu, Shuji;Wang, Junyi;Liu, Jiannan;Flicek, Paul;Searle, Steve;Wang, Jun;Kuratani, Shigeru;Yin, Ye;Aken, Bronwen;Zhang, Guojie;Irie, Naoki
海龟独特的解剖学特征引发了关于其独特身体计划起源的未解之谜。我们生成并分析了软壳龟（Pelodiscus sinensis）和绿色海龟（Chelonia mydas）的基因组草案;我们的结果表明，海龟与鸟类-鳄鱼谱系的密切关系，它们在约2.679亿至2.483亿年前（上二叠世至三叠纪）分裂。我们还发现这些海龟的嗅觉受体基因广泛扩展。胚胎基因表达分析确定了一个沙漏般的分歧龟和鸡胚胎发生，最大的保护周围的脊椎动物的典型时期，而不是在后期阶段，显示的阿托诺特常见的模式。Wnt 5a表达被发现在背壳的生长区，支持可能的co-option的肢体相关的Wnt信号在收购这种海龟特有的新奇。我们的研究结果表明，海龟的进化是伴随着一个意想不到的保守的脊椎动物类的时期，其次是海龟特定的发展模式的重新产生的新结构的壳。
The unique anatomical features of turtles have raised unanswered questions about the origin of their unique body plan. We generated and analyzed draft genomes of the soft-shell turtle (Pelodiscus sinensis) and the green sea turtle (Chelonia mydas); our results indicated the close relationship of the turtles to the bird-crocodilian lineage, from which they split ~267.9–248.3 million years ago (Upper Permian to Triassic). We also found extensive expansion of olfactory receptor genes in these turtles. Embryonic gene expression analysis identified an hourglass-like divergence of turtle and chicken embryogenesis, with maximal conservation around the vertebrate phylotypic period, rather than at later stages that show the amniote-common pattern. Wnt5a expression was found in the growth zone of the dorsal shell, supporting the possible co-option of limb-associated Wnt signaling in the acquisition of this turtle-specific novelty. Our results suggest that turtle evolution was accompanied by an unexpectedly conservative vertebrate phylotypic period, followed by turtle-specific repatterning of development to yield the novel structure of the shell.
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系统基因分析支持海龟作为姊妹鸟类和鳄鱼（Archosauria）的位置。
影响因子：
5.4
作者：
Chiari Y;Cahais V;Galtier N;Delsuc F
通讯作者：
Delsuc F
影响因子：
7
作者：
Hayden, Sara;Bekaert, Michael;Teeling, Emma C.
通讯作者：
Teeling, Emma C.
影响因子：
2.8
作者：
Endres, C. S.;Putman, N. F.;Lohmann, K. J.
通讯作者：
Lohmann, K. J.
影响因子：
14.9
作者：
Benson, G
通讯作者：
Benson, G
影响因子：
3
作者：
Camacho C;Coulouris G;Avagyan V;Ma N;Papadopoulos J;Bealer K;Madden TL
通讯作者：
Madden TL