Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions.
Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions.
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四跨果蛋白CO-029通过取消调节细胞 - 矩阵和细胞 - 细胞粘连来抑制结直肠癌细胞的运动。
DOI：
10.1371/journal.pone.0038464
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Zhang XA
中科院分区：
文献类型：
--
作者：
Guo Q;Xia B;Zhang F;Richardson MM;Li M;Zhang JS;Chen F;Zhang XA
Alterations in tetraspanin CO-029 expression are associated with the progression and metastasis of cancers in the digestive system. However, how CO-029 promotes cancer metastasis is still poorly understood. To determine the mechanism, we silenced CO-029 expression in HT29 colon cancer cells and found that the CO-029 knockdown significantly reduced cell migratory ability. The diminished cell migration was accompanied by the upregulation of both integrin-dependent cell-matrix adhesion on laminin and calcium-dependent cell-cell adhesion. The cell surface levels of laminin-binding integrin α3β1 and fibronectin-integrin α5β1 were increased while the level of CD44 was decreased upon CO-029 silencing. These changes contribute to the altered cell-matrix adhesion. The deregulated cell-cell adhesion results, at least partially, from increased activity of cadherins and reduced level of MelCAM. In conclusion, CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions.
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影响因子：
8.8
作者：
de Both NJ;Vermey M;Dinjens WN;Bosman FT
通讯作者：
Bosman FT
影响因子：
11.2
作者：
Greco, Celine;Bralet, Marie-Pierre;Boucheix, Claude
通讯作者：
Boucheix, Claude
影响因子：
15.9
作者：
Conacci-Sorrell, M;Zhurinsky, J;Ben-Ze'ev, A
通讯作者：
Ben-Ze'ev, A
影响因子：
4.8
作者：
Hong, In-Kee;Jin, Young-June;Lee, Hansoo
通讯作者：
Lee, Hansoo
DOI：
10.1083/jcb.132.6.1199
发表时间：
1996-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bartolazzi A;Nocks A;Aruffo A;Spring F;Stamenkovic I
通讯作者：
Stamenkovic I