Novel imaging markers for altered cerebrovascular morphology in aging, stroke, and Alzheimer's disease.
Novel imaging markers for altered cerebrovascular morphology in aging, stroke, and Alzheimer's disease.
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DOI：
10.1111/jon.13023
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发表时间：
2022-09
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影响因子：
--
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中科院分区：
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脑血管系统改变是多种神经系统疾病的关键现象。本文对健康和患病成人的血管形态进行了定量评估，包括衰老过程中的变化和威利斯环 (CoW) 的解剖变化。我们使用我们新颖的自动方法从 175 名健康受试者的 MR 血管造影扫描中分割和提取脑血管系统的几何特征，这些特征用于创建脑血管系统的概率图集并研究 CoW 解剖学的正常衰老和受试者间差异。随后，我们量化并分析了 45 名急性缺血性中风 (AIS) 和 50 名阿尔茨海默病 (AD) 患者的血管变化，这是两种主要的脑血管和神经退行性疾病。在抽样队列中，我们确定只有 35% 的健康成年人的 CoW 完全形成，并发现随着年龄的增加以及 AIS 和 AD 疾病的发生，弯曲度和分形度显着增加（p<0.05）。正如预期的那样，我们还发现 AIS 患者的血管长度、体积和分支数量显着减少。与年龄匹配的健康成年人相比，AD 脑血管的直径明显更小，分支模式更复杂。这些变化在健康、早发性轻度 AD 组和中度/重度痴呆组之间显着加剧 (p<0.05)。尽管由于缺乏此类数据集，我们的研究不包括纵向数据，但特定的几何特征和定量比较证明了使用血管形态作为神经系统疾病的非侵入性成像生物标志物的潜力。
Altered brain vasculature is a key phenomenon in several neurologic disorders. This paper presents a quantitative assessment of vascular morphology in healthy and diseased adults including changes during aging and the anatomical variations in the Circle of Willis (CoW). We used our novel automatic method to segment and extract geometric features of the cerebral vasculature from MR angiography scans of 175 healthy subjects, which were used to create a probabilistic atlas of cerebrovasculature and to study normal aging and inter-subject variations in CoW anatomy. Subsequently, we quantified and analyzed vascular alterations in 45 acute ischemic stroke (AIS) and 50 Alzheimer’s disease (AD) patients, two prominent cerebrovascular and neurodegenerative disorders. In the sampled cohort, we determined that the CoW is fully formed in only 35% of healthy adults and found significantly (p<0.05) increased tortuosity and fractality, with increasing age and also with disease in both AIS and AD. We also found significantly lower vessel length, volume and number of branches in AIS patients, as expected. The AD cerebral vessels exhibited significantly smaller diameter and more complex branching patterns, compared to age-matched healthy adults. These changes were significantly heightened (p<0.05) between healthy, early onset mild AD and moderate/severe dementia groups. Although our study does not include longitudinal data due to paucity of such datasets, the specific geometric features and quantitative comparisons demonstrate the potential for using vascular morphology as a non-invasive imaging biomarker for neurologic disorders.
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影响因子：
4.8
作者：
Klohs J;Rudin M;Shimshek DR;Beckmann N
通讯作者：
Beckmann N
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影响因子：
1.9
作者：
Chandra A;Li WA;Stone CR;Geng X;Ding Y
通讯作者：
Ding Y
影响因子：
20.1
作者：
Donato AJ;Machin DR;Lesniewski LA
通讯作者：
Lesniewski LA
影响因子：
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作者：
Bullitt, Elizabeth;Zeng, Donglin;Mortamet, Benedicte;Ghosh, Arpita;Aylward, Stephen R.;Lin, Weili;Marks, Bonita L.;Smith, Keith
通讯作者：
Smith, Keith
DOI：
10.1007/s10334-009-0194-y
发表时间：
2010-02-01
影响因子：
2.3
作者：
El Tayara, Nadine El Tannir;Delatour, Benoit;Dhenain, Marc
通讯作者：
Dhenain, Marc