The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography.
The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography.
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DOI：
10.1016/j.neurobiolaging.2008.03.022
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发表时间：
2010-02
影响因子：
4.2
通讯作者：
Smith, Keith
中科院分区：
文献类型：
--
作者：
Bullitt, Elizabeth;Zeng, Donglin;Mortamet, Benedicte;Ghosh, Arpita;Aylward, Stephen R.;Lin, Weili;Marks, Bonita L.;Smith, Keith
组织学和磁共振成像研究表明，与年龄相关的人类大脑变化可能至少部分与血管变化有关。然而，关于与健康老龄化相关的血管变化的信息相对较少。本文介绍的研究检查了100名健康志愿者（50名男性，50名女性）的标准化高分辨率磁共振血管造影（MRA）分割的血管，年龄在18-74岁之间，没有高血压或其他可能影响血管系统的疾病。受试者样本分为5个年龄组（n=20/组），每组性别均匀分布。检查大脑前部、大脑中部和后部循环的血管数量、血管半径和血管迂曲度。无论年龄大小，雄性动物在所有解剖区域均表现出较大的血管半径。随着年龄的增长，男性和女性的MRA可辨别血管数量均减少，最明显的是后循环。血管造影相关的迂曲度增加相对较轻。我们的多模态图像数据库已公开供其他研究人员使用。
Histological and magnetic resonance imaging studies have demonstrated that age-associated alterations of the human brain may be at least partially related to vascular alterations. Relatively little information has been published on vascular changes associated with healthy aging, however. The study presented in this paper examined vessels segmented from standardized, high-resolution, magnetic resonance angiograms (MRA) of 100 healthy volunteers (50 males, 50 females), aged 18-74, without hypertension or other disease likely to affect the vasculature. The subject sample was divided into 5 age groups (n=20/group) with gender equally distributed per group. The anterior cerebral, both middle cerebral, and the posterior circulations were examined for vessel number, vessel radius, and vessel tortuosity. Males exhibited larger vessel radii regardless of age and across all anatomical regions. Both males and females displayed a lower number of MRA-discernible vessels with age, most marked in the posterior circulation. Age-associated tortuosity increases were relatively mild. Our multi-modal image database has been made publicly available for use by other investigators.
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影响因子：
10.9
作者：
Bullitt, E;Aylward, S;Muller, K
通讯作者：
Muller, K
影响因子：
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通讯作者：
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作者：
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通讯作者：
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