Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis.
Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis.
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DOI：
10.1186/ar3316
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发表时间：
2011-04-15
影响因子：
4.9
通讯作者：
Dahlbäck B
中科院分区：
文献类型：
--
作者：
Wu J;Ekman C;Jönsen A;Sturfelt G;Bengtsson AA;Gottsäter A;Lindblad B;Lindqvist E;Saxne T;Dahlbäck B
Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI). ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI. Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score (SLEDAI). In contrast, in patients with RA, the sMer levels did not correlate with the disease activity score (DAS). In SLE, sMer levels were particularly high in those with lupus nephritis, patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy, the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score. The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA, suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular, sMer was increased in SLE, the plasma levels of sMer reflecting disease activity.
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影响因子：
2.8
作者：
Ekman, Carl;Gottsater, Anders;Dahlback, Bjorn
通讯作者：
Dahlback, Bjorn
影响因子：
27.4
作者：
Lindqvist, E;Jonsson, K;Eberhardt, K
通讯作者：
Eberhardt, K
影响因子：
4.3
作者：
Barani, J;Nilsson, JÅ;Gottsäter, A
通讯作者：
Gottsäter, A
影响因子：
32.4
作者：
A-Gonzalez, Noelia;Bensinger, Steven J.;Hong, Cynthia;Beceiro, Susana;Bradley, Michelle N.;Zelcer, Noam;Deniz, Jose;Ramirez, Cristina;Diaz, Mercedes;Gallardo, German;Ruiz de Galarreta, Carlos;Salazar, Jon;Lopez, Felix;Edwards, Peter;Parks, John;Andujar, Miguel;Tontonoz, Peter;Castrillo, Antonio
通讯作者：
Castrillo, Antonio
缺乏C-MER膜酪氨酸激酶的小鼠中延迟的凋亡细胞清除和狼疮样自身免疫性。
DOI：
10.1084/jem.20012094
发表时间：
2002-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cohen PL;Caricchio R;Abraham V;Camenisch TD;Jennette JC;Roubey RA;Earp HS;Matsushima G;Reap EA
通讯作者：
Reap EA