The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis.
The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis.
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DOI：
10.1007/s11914-012-0132-1
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发表时间：
2013-03
影响因子：
4.3
通讯作者：
Rubin, Clinton T.
中科院分区：
文献类型：
--
作者：
Chan, M. Ete;Uzer, Gunes;Rubin, Clinton T.
关键词：
利用振动向骨骼传递机械信号被认为是治疗骨质疏松症的一种非药物疗法。振动在一定的幅度和频率范围内传递，对肌肉骨骼组织既有合成代谢作用，又有抗分解代谢作用，但必须特别注意，因为这些机械信号，特别是长期暴露在较高强度下，是许多生理系统的已知病原体。相比之下，越来越多的临床前和临床证据表明，低强度振动(LIV)通过调节负责骨重建的细胞的活性，以及偏向其间充质干细胞和造血干细胞前体细胞的分化命运来改善骨质量。体外研究为LIV的生物学机制提供了深入的见解，并表明细胞通过一种不同的机制对这些低强度信号做出反应，而不是由基质应变驱动，而是由加速驱动。这些细胞、动物和人体研究可能代表着一种安全的、非药物手段的基础，以保护和改善老年人、受伤和虚弱的肌肉骨骼系统。
The delivery of mechanical signals to the skeleton using vibration is being considered as a non-drug treatment of osteoporosis. Delivered over a range of magnitudes and frequencies, vibration has been shown to be both anabolic and anti-catabolic to the musculoskeletal tissues, yet caution must be emphasized as these mechanical signals, particularly chronic exposure to higher intensities, is a known pathogen to many physiological systems. In contrast, accumulating preclinical and clinical evidence indicates that low intensity vibration (LIV) improves bone quality through regulating the activity of cells responsible for bone remodeling, as well as biasing the differentiation fate of their mesenchymal and hematopoietic stem cell progenitors. In vitro studies provide insights into the biologic mechanisms of LIV, and indicate that cells respond to these low magnitude signals through a distinct mechanism driven not by matrix strain but acceleration. These cell, animal and human studies may represent the foundation of a safe, non-drug means to protect and improve the musculoskeletal system of the elderly, injured and infirm.
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影响因子：
2.8
作者：
Goodship, Allen E.;Lawes, Timothy J.;Rubin, Clinton T.
通讯作者：
Rubin, Clinton T.
影响因子：
4
作者：
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
2.3
作者：
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通讯作者：
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